Results 11 to 20 of about 11,495 (207)
Diverse viral proteases activate the NLRP1 inflammasome [PDF]
eLife, 2021 The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of ...
Brian V Tsu +5 more
doaj +4 more sources
NLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise
Communications Biology, 2023 NLRP1, while the first inflammasome described, has only recently begun to gain significant attention in disease pathology, inflammation research, and potentially, as a therapeutic target. Recently identified human variants provide key insights into NLRP1
Kristian Barry +2 more
doaj +3 more sources
Characterization of the NLRP1 inflammasome response in bovine species [PDF]
Innate Immunity, 2020 Inflammasomes act as sensors of infection or damage to initiate immune responses. While extensively studied in rodents, understanding of livestock inflammasomes is limited.
Catherine E Vrentas +4 more
doaj +3 more sources
INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS
Медицина в Кузбассе, 2023 The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any ...
Денис Сергеевич Загрешенко +5 more
doaj +1 more source
NLRP1 Joins the Dark Side? [PDF]
Immunity, 2012 NLRP1 has long remained an elusive member of the NOD-like-receptor family of innate immune sensors. In this issue of Immunity, Masters et al. (2012) describe its role in immune responses to stress and infection.
de Zoete, Marcel R, Flavell, Richard A
+12 more sources
The Role of NLRP1, AIM2 and MEFV Inflammasomes in the High-Intensity Interval Training of Individuals With Obesity. [PDF]
ImmunologyThis study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Silveira ALPA +8 more
europepmc +2 more sources
Cell Death and Disease, 2022 NLRP1 is the primary inflammasome sensor in human keratinocytes. Sensing of UVB radiation by NLRP1 is believed to underlie the induction of sunburn.
Paulina Hennig +4 more
doaj +1 more source
Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. [PDF]
PLoS Pathogens, 2016 Inflammasomes are cytosolic multi-protein complexes that initiate immune responses to infection by recruiting and activating the Caspase-1 protease.
Joseph Chavarría-Smith +4 more
doaj +1 more source
Indian Journal of Rheumatology, 2022 Inherited disorders of the inflammasome pathway causes dysregulated inflammasome activation, which presents with inflammation and other clinical features linked to the defective protein.
Nayan Patel Sureja, Liza Rajasekhar
doaj +1 more source
The NLRP1 inflammasome in skin diseases
Frontiers in Immunology, 2023 Healthy human skin is constantly exposed to sterile and microbial agents. The skin immune system plays an important role in immune surveillance between tolerance and immune activation. This is mainly mediated by neutrophils, macrophages and most importantly lymphocytes.
Burian, Marc +2 more
openaire +4 more sources