Results 81 to 90 of about 9,154 (185)

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes

Nature Communications, 2021
Pathogen triggered N-terminal degradation of NLRP1 and CARD8 by the proteasome releases their C-terminal UPA-CARD fragments (CT) to form the inflammasome, which in turn activates caspase-1. Here, the authors present the cryo-EM structures of the NLRP1-CT
L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswold, Jianbin Ruan, Humayun Sharif, Pietro Fontana, Elizabeth L. Orth-He, Tian-Min Fu, Daniel A. Bachovchin, Hao Wu   +10 more
doaj   +1 more source

Analysis of inflammasomes and antiviral sensing components reveals decreased expression of NLRX1 in HIV-positive patients assuming efficient antiretroviral therapy [PDF]

, 2015
Objective: Few studies have investigated the importance of different components of the inflammasome system and of innate mitochondrial sensing (IMS) pathways in HIV infection and its treatment.
Bianchini, Elena, Borghi, Vanni, Carnevale, Gianluca, Cossarizza, Andrea, DE BIASI, Sara, Digaetano, Margherita, Gibellini, Lara, Guaraldi, Giovanni, Mussini, Cristina, Nasi, Milena, Pecorini, Simone, Pinti, Marcello   +11 more
core   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Study on the Modulation of NLRP1 by Natural Products in Neurodegenerative Diseases

Natural Product Communications
Neuronal pyroptosis is one of the crucial pathogenesis of neurodegenerative diseases, and the signaling pathway mediated by inflammasome is the main pathway of pyroptosis.
Ting-ting Wang, Xin-tong Zuo, Ling Cheng, Nan Shao, Peng Zhou   +4 more
doaj   +1 more source

Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

BMC Neuroscience, 2011
Background Members of the mammalian nucleotide binding domain, leucine-rich repeat (LRR)-containing receptor (NLR) family of proteins are key modulators of innate immunity regulating inflammation.
Mawhinney Lana J, de Vaccari Rivero Juan, Dale Gordon A, Keane Robert W, Bramlett Helen M   +4 more
doaj   +1 more source

Insights into assembly of the macromolecular inflammasome complex [PDF]

, 2014
This is the published version. It first appeared at http://www.degruyter.com/view/j/infl.2013.1.issue-1/infl-2014-0009/infl-2014-0009.xml.AbstractDramatic advances in our understanding of the ultrastructure of the inflammasome and the molecular ...
Boyle, Joseph P, Monie, Tom P
core   +2 more sources

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

NLRP3/1-mediated pyroptosis: beneficial clues for the development of novel therapies for Alzheimer’s disease

Neural Regeneration Research
The inflammasome is a multiprotein complex involved in innate immunity that mediates the inflammatory response leading to pyroptosis, which is a lytic, inflammatory form of cell death.
Bo Hu, Jiaping Zhang, Jie Huang, Bairu Luo, Xiansi Zeng, Jinjing Jia   +5 more
doaj   +1 more source

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome. [PDF]

PLoS Pathogens, 2012
NOD-like receptor (NLR) proteins (Nlrps) are cytosolic sensors responsible for detection of pathogen and danger-associated molecular patterns through unknown mechanisms.
Jonathan L Levinsohn, Zachary L Newman, Kristina A Hellmich, Rasem Fattah, Matthew A Getz, Shihui Liu, Inka Sastalla, Stephen H Leppla, Mahtab Moayeri   +8 more
doaj   +1 more source