Results 21 to 30 of about 9,154 (185)

Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome [PDF]

Cell Death and Disease, 2021
Cytosolic inflammasomes are supramolecular complexes that are formed in response to intracellular pathogens and danger signals. However, as to date, the detailed description of a homotypic caspase recruitment domain (CARD) interaction between NLRP1 and ...
Zhihao Xu, Ying Zhou, Muziying Liu, Huan Ma, Liangqi Sun, Ayesha Zahid, Yulei Chen, Rongbin Zhou, Minjie Cao, Dabao Wu, Weidong Zhao, Bofeng Li, Tengchuan Jin   +12 more
doaj   +2 more sources

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells [PDF]

Immunity, 2012
Cytopenias are key prognostic indicators of life-threatening infection, contributing to immunosuppression and mortality. Here we define a role for Caspase-1-dependent death, known as pyroptosis, in infection-induced cytopenias by studying inflammasome activation in hematopoietic progenitor cells.
Masters, S.L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J.A., McArthur, K., Baldwin, T.M., Chevrier, S., Nowell, C.J., Cengia, L.H., Henley, K.J., Collinge, J.E., Kastner, D.L., Feigenbaum, L., Hilton, D.J., Alexander, W.S., Kile, B.T., Croker, B.A.   +18 more
openaire   +5 more sources

NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer’s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal Loss [PDF]

Cells, 2022
Neuroinflammation is one of the core pathological features of Alzheimer’s disease (AD) as both amyloid β (Aβ) and tau monomers and oligomers can trigger the long-term pro-inflammatory phenotype of microglial cells with consequent overactivation of the ...
Ena Španić, Lea Langer Horvat, Katarina Ilić, Patrick R. Hof, Goran Šimić   +4 more
doaj   +2 more sources

Genetic Analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol [PDF]

Frontiers in Genetics, 2014
The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease, and have also been associated with longevity.
Mary F Feitosa, Mary Kaye Wojczynski, Robert eStraka, Candace M Kammerer, Joseph H Lee, Aldi T Kraja, Kaare eChristensen, Anne B Newman, Michael M Province, Ingrid B Borecki   +9 more
doaj   +4 more sources

Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells. [PDF]

PLoS Biology
Despite the success of antiretroviral therapy in suppressing plasma viremia in people living with human immunodeficiency virus type-1 (HIV-1), persistent viral RNA expression in tissue reservoirs is observed and can contribute to HIV-1-induced ...
Sallieu Jalloh, Ivy K Hughes, Hisashi Akiyama, Aldana D Gojanovich, Andres A Quiñones-Molina, Mengwei Yang, Andrew J Henderson, Gustavo Mostoslavsky, Suryaram Gummuluru   +8 more
doaj   +2 more sources

INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS

Медицина в Кузбассе, 2023
The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any ...
Денис Сергеевич Загрешенко, Андрей Владимирович Климов, Владимир Васильевич Климов, Наталья Сергеевна Кошкарова, Оксана Анатольевна Найдина, Екатерина Юрьевна Цыплина   +5 more
doaj   +1 more source

The NLRP1 inflammasome in skin diseases. [PDF]

Front Immunol, 2023
Healthy human skin is constantly exposed to sterile and microbial agents. The skin immune system plays an important role in immune surveillance between tolerance and immune activation. This is mainly mediated by neutrophils, macrophages and most importantly lymphocytes.
Burian M, Schmidt MF, Yazdi AS.
europepmc   +5 more sources

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii. [PDF]

PLoS Pathogens, 2014
Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome
Kimberly M Cirelli, Gezahegn Gorfu, Musa A Hassan, Morton Printz, Devorah Crown, Stephen H Leppla, Michael E Grigg, Jeroen P J Saeij, Mahtab Moayeri   +8 more
doaj   +8 more sources

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity [PDF]

mBio
Toxoplasma gondii is an intracellular parasite that can activate the NLRP1 inflammasome leading to macrophage pyroptosis in Lewis rats, but the underlying mechanism is not well understood.
Yifan Wang, L. Robert Hollingsworth, Lamba Omar Sangaré, Tatiana C. Paredes-Santos, Shruthi Krishnamurthy, Bennett H. Penn, Hao Wu, Jeroen P. J. Saeij   +7 more
doaj   +2 more sources

The NLRP1 and CARD8 inflammasomes [PDF]

Immunological Reviews, 2020
AbstractInflammasomes are multiprotein complexes that activate inflammatory cytokines and induce pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are related germline‐encoded pattern recognition receptors that form inflammasomes, but their activation mechanisms and biological purposes have not yet been fully ...
Cornelius Y. Taabazuing, Andrew R. Griswold, Daniel A. Bachovchin   +2 more
openaire   +2 more sources