Results 11 to 20 of about 9,154 (185)

Characterization of the NLRP1 inflammasome response in bovine species [PDF]

Innate Immunity, 2020
Inflammasomes act as sensors of infection or damage to initiate immune responses. While extensively studied in rodents, understanding of livestock inflammasomes is limited.
Catherine E Vrentas, Paola M Boggiatto, Steven C Olsen, Stephen H Leppla, Mahtab Moayeri   +4 more
doaj   +5 more sources

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome. [PDF]

Sci Immunol, 2022
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We found that oxidized TRX1 associates with the NACHT-LRR region of NLRP1 in an ATP-dependent process, forming a stable complex that restrains inflammasome activation ...
Ball DP, Tsamouri LP, Wang AE, Huang HC, Warren CD, Wang Q, Edmondson IH, Griswold AR, Rao SD, Johnson DC, Bachovchin DA.   +10 more
europepmc   +5 more sources

The NLRP1 Inflammasome in Human Skin and Beyond. [PDF]

Int J Mol Sci, 2020
Inflammasomes represent a group of protein complexes that contribute to host defense against pathogens and repair processes upon the induction of inflammation. However, aberrant and chronic inflammasome activation underlies the pathology of numerous common inflammatory diseases. Inflammasome assembly causes activation of the protease caspase-1 which in
Fenini G, Karakaya T, Hennig P, Di Filippo M, Beer HD.   +4 more
europepmc   +7 more sources

ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome. [PDF]

Science, 2022
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune sensor predominantly expressed in the skin and airway epithelium. Here, we report that human NLRP1 senses the ultraviolet B (UVB)- and toxin-induced ribotoxic stress response (RSR).
Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Ho L, Wu B, Hornung V, Zhong FL.   +27 more
europepmc   +6 more sources

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation [PDF]

Nature, 2021
Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine maturation and pyroptosis1-4. Gain-of-function mutations of NLRP1 cause severe inflammatory diseases of the skin4-6.
L. Robert Hollingsworth, Humayun Sharif, Andrew R. Griswold, Pietro Fontana, Julian Mintseris, Kevin B. Dagbay, Joao A. Paulo, Steven P. Gygi, Daniel A. Bachovchin, Hao Wu   +9 more
openaire   +5 more sources

Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling

Frontiers in Immunology, 2023
Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon in the air, triggers pulmonary inflammation. This study focused on BaP-induced inflammation in the alveolar epithelium. A549 cells were stimulated with BaP for four days.
Risa Kohno, Yuka Nagata, Tomohiro Ishihara, Chisato Amma, Yayoi Inomata, Takafumi Seto, Ryo Suzuki   +6 more
doaj   +3 more sources

Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8

Nature Communications, 2021
NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between
Qin Gong, Kim Robinson, Chenrui Xu, Phuong Thao Huynh, Kelvin Han Chung Chong, Eddie Yong Jun Tan, Jiawen Zhang, Zhao Zhi Boo, Daniel Eng Thiam Teo, Kenneth Lay, Yaming Zhang, John Soon Yew Lim, Wah Ing Goh, Graham Wright, Franklin L. Zhong, Bruno Reversade, Bin Wu   +16 more
doaj   +2 more sources

1,25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal keratinocytes [PDF]

Redox Biology, 2021
The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein (NLRP) inflammasome is a key inflammatory signaling pathway activated via a two-step signaling process consisting of priming and activation steps.
Takahisa Nakajo, Takeshi Katayoshi, Natsuko Kitajima, Kentaro Tsuji-Naito   +3 more
doaj   +2 more sources

BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome [PDF]

Frontiers in Immunology
IntroductionPreeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear ...
Man Zhao, Zexin Yang, Yan Kang, Zhenya Fang, Changqing Zhang, Chunying Wang, Meijuan Zhou, Junjun Guo, Anna Li, Meihua Zhang   +9 more
doaj   +2 more sources

Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice [PDF]

Journal of Neuroinflammation
Background Major depressive disorder (MDD) is a common but severe psychiatric illness characterized by depressive mood and diminished interest. Both nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 1 (NLRP1 ...
Ya-Jing Zhu, Jing Huang, Ru Chen, Yu Zhang, Xin He, Wen-Xin Duan, Yuan-Lei Zou, Meng-Mei Sun, Hui-Li Sun, Si-Min Cheng, Hao-Chuan Wang, Hao Zhang, Wen-Ning Wu   +12 more
doaj   +2 more sources