Results 71 to 80 of about 11,495 (207)

UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody

Frontiers in Immunology, 2022
NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes.
Yuya Murase, Takuya Takeichi, Jun Koseki, Yuki Miyasaka, Yoshinao Muro, Tamio Ohno, Teppei Shimamura, Masashi Akiyama   +7 more
doaj   +1 more source

C6orf10 low-frequency and rare variants in italian multiple sclerosis patients [PDF]

, 2019
In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies.
Balestra, Dario, Benazzo, Andrea, Bernardi, Francesco, Bovolenta, Matteo, Bozzini, Nicolò, Gemmati, Donato, Guidi, Irene, Laino, Lorenza Anna, Lunghi, Barbara, Marchetti, Giovanna, Menegatti, Erica, Meneghetti, Silvia, Salvi, Fabrizio, Scapoli, Chiara, Straudi, Sofia, Zamboni, Paolo, Ziliotto, Nicole   +16 more
core   +2 more sources

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Association of Single Nucleotide Polymorphisms in Nucleotide-Binding Domain Leucine-Rich Repeat Protein 1 with Clostridioides difficile Colonization or Infection

Infection and Drug Resistance, 2023
Bo-Yang Tsai,1,* Pei-Jane Tsai,1– 4,* Ching-Chi Lee,5,6 Chun-Wei Chiu,7 Yi-Hsin Lai,4 Jen-Chieh Lee,6 Wen-Chien Ko,6,8 Yuan-Pin Hung6– 9 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan ...
Tsai BY, Tsai PJ, Lee CC, Chiu CW, Lai YH, Lee JC, Ko WC, Hung YP   +7 more
doaj  

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii [PDF]

, 2013
Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the activation of the innate immune response. In this study, we investigated the role of cytoplasmic nucleotide-binding domain and leucine-rich repeat ...
Cirelli, Kimberly, Crown, Devorah, Gorfu, Gezahegn, Grigg, Michael E., Koller, Beverly H., Leppla, Stephen H., Masters, Seth, Mayer-Barber, Katrin, Melo, Mariane Bandeira, Moayeri, Mahtab, Saeij, Jeroen, Sher, Alan   +11 more
core   +4 more sources

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Simultaneous Effect of Aerobic Exercise and Octapamine on Tissue Levels of NLRP1, Leptin, Carbonyl Protein and Inflammatory Histological Changes of Brown Adipose Tissue in Rats Fed with Deep Heated

Armaghane Danesh Bimonthly Journal, 2021
Background & aim: Consumption of crunchy foods and lack of nutritional hygiene causes destruction of adipose tissue homeostasis and secretion of inflammatory factors. Aerobic exercise is one of the ways to control inflammation adipose tissue.
N Darvishzadeh, K Aziz Beigi, Z Etemad
doaj  

The “Tianyu” Formulation Alleviates Rheumatoid Arthritis by Modulating the NLRP3/Caspase‐1/GSDMD‐Mediated Pyroptosis Pathway

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Proposed signaling pathway by which TY modulates NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis. ABSTRACT This research focuses on exploring the modulation of pyroptosis and its underlying mechanisms via the “Tianyu” formulation (TY), a traditional Chinese medicine, in human rheumatoid arthritis fibroblast‐like synovial cells (RA‐HFLS) and a collagen ...
Yueya Zhu, Xinying Cai, Qiuhan Zheng, Chunqiu Fang, Zhi Pan, Yinghang Wang   +5 more
wiley   +1 more source

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.

PLoS Pathogens, 2014
Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome
Kimberly M Cirelli, Gezahegn Gorfu, Musa A Hassan, Morton Printz, Devorah Crown, Stephen H Leppla, Michael E Grigg, Jeroen P J Saeij, Mahtab Moayeri   +8 more
doaj   +1 more source

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]

, 2016
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E, Birrell, M, Holden, D, Jennings, E, Matthews, S, Shao, F, Shenoy, A, Thurston, T   +7 more
core   +1 more source