Results 121 to 130 of about 9,154 (185)

Is the inflammasome a potential therapeutic target in renal disease? [PDF]

, 2014
The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cytoplasmic trigger inflammasome assembly. These
A Chen, A Covic, A Dorfleutner, A Fukami, A Granfeldt, A MacKenzie, A So, A Vilaysane, AA Shigeoka, AH Bani-Hani, AJ Puren, AM Karkar, AM Karkar, AN Economides, AS Yazdi, BA VanderBrink, BJ Pereira, C Dostert, C Hammerberg, CA Dinarello, CA Dinarello, CA Dinarello, CA Dinarello, CJ Chen, CL Edelstein, CL Myers, Clare M Turner, CM Turner, CM Turner, CM Yang, CR Parikh, D Choubey, D Ferrari, D Ferrari, D Nordstrom, D Sola-Villa, DG Perregaux, E Homsi, EA Kurt-Jones, EA Miao, EC Keystone, ED Siew, EM Kofoed, F Bauernfeind, F Knauf, F Turkmen, FG Bauernfeind, Frederick WK Tam, FW Tam, FW Tam, G Dell’Antonio, G Dell’Antonio, G Kaplanski, G Nuki, G Ren, GY Chen, H Harada, H Kohka, H Ranjbaran, H Saiga, H von Bernuth, H Wu, H Yamagishi, H Zhang, HJ Lachmann, HM Hoffman, HU Schorlemmer, HY Lan, I Jalilian, IC Allen, J Lichtnekert, J Wang, JC Morel, JL Levinsohn, JM Bruey, JM Kahlenberg, JR Timoshanko, K Furuichi, K Kersse, K Kinoshita, K Matsumoto, K Rusai, K Takeda, K Wareham, KL Williams, KM Sumpter, LK Parvathenani, M Hacham, M Haq, M Lech, M Mizobuchi, M Shiohara, M Sugiyama, M Takeuchi, M Tomura, MD Wewers, Mervyn Singer, MP Bevilacqua, N Arulkumaran, N Arulkumaran, N Kolliputi, N Ueno, NA Thornberry, NB Bryan, NB Bryan, Nishkantha Arulkumaran, O Gross, O Hertting, O Vonend, R Alten, R Goldbach-Mansky, R Imamura, RG Goncalves, Robert J Unwin, S Cornelis, S Deplano, S Gangemi, S Gauer, SC Whitman, SL Fernando, SL Fink, SR Ali, SR Mulay, SR Taylor, SR Taylor, SS Iyer, T Bergsbaken, T Bergsbaken, T Dao, T Fujita, T Porazko, TL Roberts, U Kavita, V Hurgin, V Pascual, W Wang, X Wang, Y Chung, Y le Meur, Y Liu, Y Zhao, Z Mallat, Z Ye   +142 more
core   +1 more source

NLRP1 inflammasome activation in schizophrenia

FENS Forum 2024
Abstract body: Aims: In the context of the maternal immune activation and neuroinflammation hypotheses of schizophrenia (SZ), we studied NLRP1 mRNA and protein expression in the postmortem brain tissue from a total of 10 SZ and 10 controls. Methods: RNA underwent reverse transcription and was hybridized onto the Affymetrix HG-U133 Plus 2.0 array, using
Krsnik, Željka, Mladinov, Mihovil, Šimić, Goran, Šagud, Marina, Marčinko, Darko, Babić Leko, Mirjana, Langer Horvat, Lea, Kopić, Janja   +7 more
openaire   +1 more source

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? [PDF]

, 2015
Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory ...
Abais, Justine M., Boini, Krishna M., Li, Pin-Lan, Xia, Min, Zhang, Yang   +4 more
core   +2 more sources

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury [PDF]

, 2018
Acute exposure to ionizing radiation induces massive cell death and severe damage to tissues containing actively proliferating cells, including bone marrow and the gastrointestinal tract.
Cetinbas, Naniye, Eisenbarth, Stephanie C., Elinav, Eran, Fitzgerald, Katherine A., Flavell, Richard A., Henao-Mejia, Jorge, Hu, Bo, Jin, Chengcheng, Lam, Fred Chiu-Lai, Li, Hua-Bing, Ouyang, Xinshou, Strowig, Till, Tong, Jiyu, Yilmaz, Omer, Zhao, Chen, Zhu, Shu   +15 more
core   +1 more source

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

Nature Communications, 2018
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby ...
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters   +25 more
doaj   +1 more source

DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages

Life Science Alliance, 2019
This study shows that caspase-1 autocleavage, ASC speck assembly, and mature IL-1β and IL-18 secretion accompany rapid DPP8/DPP9-regulated pyroptosis induction in macrophages expressing a LeTx-responsive Nlrp1b allele.
Nathalia M de Vasconcelos, Gwendolyn Vliegen, Amanda Gonçalves, Emilie De Hert, Rosa Martín-Pérez, Nina Van Opdenbosch, Anvesh Jallapally, Ruth Geiss-Friedlander, Anne-Marie Lambeir, Koen Augustyns, Pieter Van Der Veken, Ingrid De Meester, Mohamed Lamkanfi   +12 more
doaj   +1 more source

p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p

Cell Death and Disease
The inflammasome sensor NLRP1 is mainly expressed by epithelial cells including keratinocytes of human skin. Germline gain-of-function mutations in NLRP1 cause inflammatory skin syndromes and predispose patients to the development of cutaneous squamous ...
Paulina Hennig, Patrick Turko, Michela Di Filippo, Mitchell P. Levesque, Thomas Kündig, Hans-Dietmar Beer   +5 more
doaj   +1 more source

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

PLoS Pathogens, 2010
Anthrax lethal toxin (LT) is a bipartite protease-containing toxin and a key virulence determinant of Bacillus anthracis. In mice, LT causes the rapid lysis of macrophages isolated from certain inbred strains, but the correlation between murine ...
Zachary L Newman, Morton P Printz, Shihui Liu, Devorah Crown, Laura Breen, Sharmina Miller-Randolph, Pamela Flodman, Stephen H Leppla, Mahtab Moayeri   +8 more
doaj   +1 more source

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia

Biomolecules
Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction.
Ena Španić Popovački, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, Mirjana Babić Leko, Mihaela Pravica, Željka Krsnik, Darko Marčinko, Marina Šagud, Patrick R. Hof, Mihovil Mladinov, Goran Šimić   +14 more
doaj   +1 more source

Inhibitory Effects of Ethanol on the NLRP3 Inflammasome [PDF]

, 2015
Immunosuppression is a major complication of alcoholism and contributes to increased rates of opportunistic infections and sepsis associated with the addiction.
Hoyt, Laura Rose
core   +1 more source