Results 101 to 110 of about 135,870 (288)

Empagliflozin Inhibits OSCC Proliferation and Migration by Suppressing SLC2A3 and NLRP3

Namık Kemal Tıp Dergisi
Aim: High glucose and inflammation facilitate oral squamous cell carcinoma (OSCC) progression. The glucose transporter solute carrier family 2 member 3 (SLC2A3) and the nucleotide-binding oligomerization domain, leucine-rich repeat-containing family ...
Gülçin TEZCAN
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

MiR-193b-3p Regulates Gasdermin-D/NLRP3 by Targeting the Signaling Axis Inhibition of Pyroptosis Attenuates Myocardial Ischemia-Reperfusion Injury

Journal of Physiological Investigation
The complex pathogenesis of myocardial ischemia-reperfusion (I/R) injury is a major factor influencing clinical prognosis. It has been confirmed that microRNAs are involved in myocardial I/R injury, and that pyroptosis is closely associated with its ...
Chao Yu, Qiu-Ping Zhu, Wei Xie, Wen-Sheng Xu, Jin-Long Liu, Wei Wang, Yi-Fan Zhang, Tao Zhang, Guo Shao   +8 more
doaj   +1 more source

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome [PDF]

, 2016
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases.
Alcocer-Gómez, Elísabet, Bullon, Pedro, Carrión, Ángel Manuel, Garrido Maraver, Juan, Marín-Aguilar, Fabiola, Román Malo, Lourdes Victoria   +5 more
core  

FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation

Cell Reports
The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by inherited mutations and contributes to the pathogenesis of several chronic inflammatory diseases. In this study, we discovered that disulfiram, a safe US Food and Drug Administration (FDA)-approved drug, specifically inhibits the NLRP3 inflammasome but not the NLRC4 or AIM2 ...
Jie Xu, Joseph M. Pickard, Gabriel Núñez   +2 more
openaire   +2 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative Drugs

Frontiers in Bioscience-Landmark
The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome is a multiprotein complex fundamental for the secretion of pro-inflammatory cytokines during the innate immune response.
Giulia Zudeh, Sara Sossai, Jacopo Angelini, Gabriele Stocco, Marianna Lucafò   +4 more
doaj   +1 more source

ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3

International Immunopharmacology
The NOD-like receptor family protein 3 (NLRP3) inflammasome is a crucial complex for the host to establish inflammatory immune responses and plays vital roles in a series of disorders, including Alzheimer's disease and acute peritonitis. However, its regulatory mechanism remains largely unclear.
Danhui Qin, Caiwei Wang, Rongzhen Yan, Ying Qin, Zhendong Ying, Hongyi Kong, Wei Zhao, Lei Zhang, Hui Song   +8 more
openaire   +2 more sources

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Knocking In the NLRP3 Inflammasome [PDF]

Immunity, 2009
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
openaire   +2 more sources