Results 111 to 120 of about 150,409 (337)

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Assessment of the inflammatory response in convalescents of a new coronavirus infection in the catamnesis

Acta Biomedica Scientifica
Background. The  pathogenetic mechanism of  the  development of  a  prolonged systemic inflammatory process in patients who have suffered a new coronavirus infection remains an  urgent problem.
T. G. Lobova, T. I. Vitkina
doaj   +1 more source

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages [Retraction]

Journal of Inflammation Research, 2022
Duan A, Ma Z, Liu W, et al. J Inflamm Res. 2021;14:6523–6542. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article. Concerns were raised following the authors request to replace images from Figure 2 and
Duan A, Ma Z, Liu W, Shen K, Zhou H, Wang S, Kong R, Shao Y, Chen Y, Guo W, Liu F   +10 more
doaj  

Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia

, 2021
Alejandra Palomino‐Antolín, Paloma Narros‐Fernández, Víctor Farré‐Alins, Javier Sevilla‐Montero, Celine Decouty‐Pérez, Ana Belén López-Rodríguez, Núria Fernández, Luis Monge, Ana I. Casas, Marı́a J. Calzada, Javier Egea   +10 more
openalex   +2 more sources

POS0236 ROLE OF NLRP3 INFLAMMASOME-DERIVED ASC SPECKS IN ADULT-ONSET STILL’S DISEASE [PDF]

, 2023
J. Topping, James A. Poulter, Fatima Nadat, C. Carter, Jan Zernicke, International Parkinson Disease Genomics Consortium, Jürgen Rech, Bruno Fautrel, Eugen Feist, Michael McDermott   +9 more
openalex   +1 more source

Knocking In the NLRP3 Inflammasome [PDF]

Immunity, 2009
Mutations in the human NLRP3 gene cause interleukin-1beta-related autoinflammatory syndromes. In this issue of Immunity, Brydges et al. (2009) and Meng et al. (2009) report the characterization of Nlrp3 gene-targeted mice harboring mutations mimicking those causing disease in humans.
openaire   +2 more sources

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients

Open Medicine
This study investigates the effects of subclinical doses of esketamine on serum NLRP3 levels and early cognitive dysfunction in elderly ischemic stroke patients after neurointerventional procedures under general anesthesia.
Wang Lang, Ma Baoxin, Zhang Jianping
doaj   +1 more source

Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative Drugs

Frontiers in Bioscience-Landmark
The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome is a multiprotein complex fundamental for the secretion of pro-inflammatory cytokines during the innate immune response.
Giulia Zudeh, Sara Sossai, Jacopo Angelini, Gabriele Stocco, Marianna Lucafò   +4 more
doaj   +1 more source

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome [PDF]

, 2016
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases.
Alcocer-Gómez, Elísabet, Bullon, Pedro, Carrión, Ángel Manuel, Garrido Maraver, Juan, Marín-Aguilar, Fabiola, Román Malo, Lourdes Victoria   +5 more
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