Results 11 to 20 of about 162,609 (336)
The anti-inflammatory regulation of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis [PDF]
International Journal of Ophthalmology, 2020 AIM: To analyze the impact of calcitonin gene-related peptide (CGRP) in mouse keratitis after Aspergillus fumigatus (A. fumigatus) infection. METHODS: C57BL/6 mice were treated subconjunctivally with different concentrations of exogenous CGRP, and BALB ...
Ming Xu +7 more
doaj +1 more source
The NLRP3 inflammasome: contributions to inflammation-related diseases
Cellular & Molecular Biology Letters, 2023 The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18.
Ying Chen +11 more
semanticscholar +1 more source
Pharmacological Reviews, 2023 The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and effector functions to regulate inflammation in health and disease.
Qiang Ma
semanticscholar +1 more source
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Nature, 2010 The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible to atherosclerosis, suggesting that endogenous substances initiate the ...
Peter Duewell +17 more
openalex +3 more sources
The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
Frontiers in Immunology, 2023 NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Xiaoyan Zhan +4 more
semanticscholar +1 more source
Microbiota-derived acetate enhances host antiviral response via NLRP3
Nature Communications, 2023 The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production ...
Junling Niu +11 more
semanticscholar +1 more source
Science immunology, 2023 NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection, sterile inflammation, and disease, including colitis, diabetes ...
Sung Hoon Baik +5 more
semanticscholar +1 more source
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Annual Review of Immunology, 2022 As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar +1 more source
Frontiers in Aging Neuroscience, 2022 The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing ...
Hallie Blevins +3 more
semanticscholar +1 more source
Upsala Journal of Medical Sciences, 2021 Background: In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS).
Buğra Kerget +4 more
doaj +1 more source