Results 11 to 20 of about 135,870 (288)

NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation [PDF]

International Journal of Molecular Sciences, 2021
In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response.
Mahbuba Akther, Md Ezazul Haque, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee   +4 more
openaire   +2 more sources

Inhibiting the NLRP3 Inflammasome [PDF]

Molecules, 2020
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy, David Brough, Sally Freeman   +2 more
openaire   +5 more sources

CAPS and NLRP3 [PDF]

Journal of Clinical Immunology, 2019
Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory ...
Laela M. Booshehri, Hal M. Hoffman
openaire   +2 more sources

AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5 [PDF]

The Journal of Immunology, 2020
Abstract The cytosolic pattern recognition receptor NLRP3 senses host-derived danger signals and certain microbe-derived products in both humans and rodents. NLRP3 activation assembles an inflammasome complex that contains the adapter proteins ASC and caspase-1, whose activation triggers the maturation and release of the proinflammatory ...
Wei Zhao, Chong-Shan Shi, Kathleen Harrison, Il-Young Hwang, Neel R Nabar, Min Wang, John H Kehrl   +6 more
openaire   +2 more sources

Lyssavirus Matrix Protein Inhibits NLRP3 Inflammasome Assembly by Binding to NLRP3

Cell Reports, 2023
Lyssavirus is a kind of neurotropic pathogen that needs to evade peripheral host immunity to enter the central nervous system to accomplish infection. NLRP3 inflammasome activation is essential for the host to defend against pathogen invasion. This study demonstrates that the matrix protein (M) of lyssavirus can inhibit both the priming step and the ...
Baokun Sui, Jianqing Zhao, Jinxiao Wang, Jiaxin Zheng, Rui Zhou, Di Wu, Zonghui Zeng, Yueming Yuan, Zhenfang Fu, Ling Zhao, Ming Zhou   +10 more
openaire   +3 more sources

UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression [PDF]

Nature Communications, 2020
AbstractNOD-like receptor protein 3 (NLRP3) detects microbial infections or endogenous danger signals and activates the NLRP3 inflammasome, which has important functions in host defense and contributes to the pathogenesis of inflammatory diseases, and thereby needs to be tightly controlled.
Hui Song, Chunyuan Zhao, Zhongxia Yu, Qizhao Li, Rongzhen Yan, Ying Qin, Mutian Jia, Wei Zhao   +7 more
openaire   +3 more sources

ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination [PDF]

The EMBO Journal, 2019
Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3-ASC complex formation, ASC oligomerization, caspase-1 activation, and IL-1β and IL-18 production ...
Guangming Ren, Xuanyi Zhang, Yang Xiao, Wen Zhang, Yu Wang, Wenbing Ma, Xiaohan Wang, Pan Song, Lili Lai, Hui Chen, Yiqun Zhan, Jianhong Zhang, Miao Yu, Changhui Ge, Changyan Li, Ronghua Yin, Xiaoming Yang   +16 more
openaire   +2 more sources

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source

Diabetes Mellitus Promotes Atrial Structural Remodeling and PARP-1/Ikkα/NF-κB Pathway Activation in Mice

Diabetes, Metabolic Syndrome and Obesity, 2021
Tianyu Meng,1,* Jie Wang,2,3,* Manyun Tang,2 Shangyu Liu,4 Ligang Ding,4 Yang Yan5 1Department of Geriatrics, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Department of
Meng T, Wang J, Tang M, Liu S, Ding L, Yan Y   +5 more
doaj  

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source