Results 11 to 20 of about 106,369 (300)
Microbiota-derived acetate enhances host antiviral response via NLRP3
Nature Communications, 2023 The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production ...
Junling Niu +11 more
semanticscholar +1 more source
Science immunology, 2023 NLRP3 inflammasome activation is a highly regulated process for controlling secretion of the potent inflammatory cytokines IL-1β and IL-18 that are essential during bacterial infection, sterile inflammation, and disease, including colitis, diabetes ...
Sung Hoon Baik +5 more
semanticscholar +1 more source
Upsala Journal of Medical Sciences, 2021 Background: In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS).
Buğra Kerget +4 more
doaj +1 more source
The Role of NLRP3 Inflammasomes in Trained Immunity
Frontiers in Bioscience-Landmark, 2023 Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee +3 more
doaj +1 more source
An update on the regulatory mechanisms of NLRP3 inflammasome activation
Cellular & Molecular Immunology, 2021 The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex involved in the release of mature interleukin-1β and triggering of pyroptosis, which is of paramount importance in a variety of physiological and ...
Seungwha Paik +4 more
semanticscholar +1 more source
Autoimmunity, 2022 Osteoarthritis is thought to be a NLRP3-related disease. NEK7 is an essential mediator for NLRP3 inflammasome activation. This study aimed to demonstrate whether NEK7 has regulatory roles in the pathogenesis of osteoarthritis. C57BL/6 mice were subjected
Wei Sun +4 more
doaj +1 more source
Autoimmunity, 2023 Nuclear receptor subfamily 3 group C member 2 (NR3C2) has been revealed to affect the progression of multiple inflammatory diseases, while NR3C2’s efficacy in coronary artery disease (CAD) remains largely unsolved.
Xiaofan Chen +2 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Myasthenia gravis (MG) is an autoantibodies-mediated autoimmune disease with the complications of neuromuscular junction transmission. In this study, we aimed to investigate the molecular regulatory roles of pentaxin 3 (PTX3) in patients and ...
Yao Li +3 more
doaj +1 more source
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
International Journal of Molecular Sciences, 2019 The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
N. Kelley +3 more
semanticscholar +1 more source
Expression of MAPK and inflammasomes in cells of the brain in experimental Alzheimer's disease
Анналы клинической и экспериментальной неврологии, 2017 Introduction. Alzheimer's disease is a chronic neurodegenerative disease that leads to neuropsychiatric disorders and decrease in cognitive activity.
Yana V. Gorina +4 more
doaj +1 more source