Results 201 to 210 of about 131,202 (338)

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

, 2010
Alana A. Shigeoka, James L. Mueller, Amanpreet Kambo, John C. Mathison, Andrew J. King, Wesley F. Hall, Jean da Silva Correia, Richard J. Ulevitch, Hal M. Hoffman, Dianne B. McKay   +9 more
openalex   +1 more source

Identification of crucial genes for polycystic ovary syndrome and atherosclerosis through comprehensive bioinformatics analysis and machine learning

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify potential biomarkers in patients with polycystic ovary syndrome (PCOS) and atherosclerosis, and to explore the common pathologic mechanisms between these two diseases in response to the increased risk of cardiovascular diseases in patients with PCOS.
Lirong Wang, Yanli Zhang, Fan Ji, Zhenmin Si, Chengdong Liu, Xiaoke Wu, Chichiu Wang, Hui Chang   +7 more
wiley   +1 more source

Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly. [PDF]

Nat Commun
Boršić E, Ramuta TŽ, Orehek S, Kreft ME, Geyer M, Jerala R, Hafner-Bratkovič I.   +6 more
europepmc   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Investigation on Klebsiella pneumoniae in the field of extracellular vesicles

Interdisciplinary Medicine, EarlyView.
The role of extracellular vesicles in the pathogenicity and antibiotic resistance, as well as treatment and prevention of Klebsiella pneumoniae. Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia.
Junwei Wu, Yuheng Liu, Jin Su, Yi Yang, Haiyi Deng, Yilin Yang, Mengxi Yanglan, Xinyi Wu, Shiqi Luo, Yao Liao, Lifu Wang   +10 more
wiley   +1 more source

The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells

, 2010
Hendrik W. van Deventer, Joseph E. Burgents, Qing Wu, Rita-Marie T. Woodford, W. June Brickey, Irving C. Allen, Erin McElvania, Jonathan S. Serody, Jenny P.‐Y. Ting   +8 more
openalex   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

W1785 Loss of NLRP3 Signaling Results in Altered Dendritic Cells (DC) Population and Impaired Induction of Regulatory T Cells (Treg): Implications for Intestinal Inflammation

, 2010
Aito Ueno, Simon A. Hirota, Jeff Ng, Yan Li, Daniel A. Muruve, Jürg Tschopp, Paul L. Beck, Subrata Ghosh   +7 more
openalex   +1 more source

Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A [PDF]

, 2011
Chelsea A. Embry, Luigi Franchi, Gabriel Núñez, Thomas C. Mitchell   +3 more
openalex   +1 more source

4-octyl itaconate reduces human NLRP3 inflammasome constitutive activation with the cryopyrin-associated periodic syndrome p.R262W, p.D305N and p.T350M variants. [PDF]

Cell Mol Life Sci
Molina-Lopez C, Hurtado-Navarro L, O'Neill LAJ, Pelegrin P.   +3 more
europepmc   +1 more source