Results 21 to 30 of about 106,369 (300)

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Nature Communications, 2021
Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism
Pan Pan, Miaomiao Shen, Zhen-Dong Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pinjun Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu   +21 more
semanticscholar   +1 more source

Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology

Cells, 2020
The Nlrp3 inflammasome is a multiprotein complex activated by a number of bacterial products or danger signals and is involved in the regulation of inflammatory processes through caspase-1 activation.
Luca Maroni, Elisabetta Ninfole, Claudio Pinto, Antonio Benedetti, Marco Marzioni   +4 more
doaj   +1 more source

MiR-143 Targets IGF-1R to Suppress Autoimmunity in Thyroid-Associated Ophthalmopathy

Journal of Inflammation Research, 2022
Wei Tang,1,* Qian Lv,1,* Xiao Huang,2,* Yuzhen Li,2 JunJie Zou,1 Jiaoyang Zheng,1 Liangliang Sun,1 Yi Bao,1 Haiyan Chen,1 Tuo Li,1 Bei Zhang,1 Song Xue,1 Yan Song,1 Xingxing Zhang,1 Xiangfang Chen,1 Jiping Cai,2 Yongquan Shi1 1Department of ...
Tang W, Lv Q, Huang X, Li Y, Zou J, Zheng J, Sun L, Bao Y, Chen H, Li T, Zhang B, Xue S, Song Y, Zhang X, Chen X, Cai J, Shi Y   +16 more
doaj  

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)

International Journal of Molecular Medicine, 2023
The inflammasome regulates innate immunity by serving as a signaling platform. The Nod-like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1, is by far the ...
Xiaolu Zhang, Ziyu Wang, Yu-kun Zheng, Qun Yu, M. Zeng, Liding Bai, Lin-Po Yang, Maojuan Guo, Xijuan Jiang, Jiali Gan   +9 more
semanticscholar   +1 more source

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages [Retraction]

Journal of Inflammation Research, 2022
Duan A, Ma Z, Liu W, et al. J Inflamm Res. 2021;14:6523–6542. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article. Concerns were raised following the authors request to replace images from Figure 2 and
Duan A, Ma Z, Liu W, Shen K, Zhou H, Wang S, Kong R, Shao Y, Chen Y, Guo W, Liu F   +10 more
doaj  

S-Nitrosoglutathione protects acute kidney injury in septic rats by inhibiting the activation of NLRP3 inflammasome [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): We aimed to study the effect of S-nitroso glutathione (SNG) on acute kidney injury (AKI) in septic rats by regulating nucleotide oligomerization domain-like receptor protein 3 (NLRP3).Materials and Methods: Sprague Dawley rats were used to ...
Heng Fan, sun Min, Le Jian-wei, Zhu Jian-hua   +3 more
doaj   +1 more source

Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease

AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022
Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages

Journal of Inflammation Research, 2021
Ao Duan,1,* Zemeng Ma,2,* Wanshun Liu,1,* Kai Shen,1,* Hao Zhou,1,* Shunbing Wang,3 Renyi Kong,4 Yuqi Shao,5 Yunzi Chen,2 Wei Guo,6 Feng Liu1 1Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University ...
Duan A, Ma Z, Liu W, Shen K, Zhou H, Wang S, Kong R, Shao Y, Chen Y, Guo W, Liu F   +10 more
doaj  

Inhibition of Long Non-Coding RNA KCNQ1OT1 Attenuates Neuroinflammation and Neuronal Apoptosis Through Regulating NLRP3 Expression via Sponging miR-30e-3p

Journal of Inflammation Research, 2021
Aixia Song,1 Yuying Yang,2 Hongmei He,1 Jian Sun,1 Qing Chang,1 Qian Xue1 1Department of Neurology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, 075000, People’s Republic of China; 2Stroke Office, The First ...
Song A, Yang Y, He H, Sun J, Chang Q, Xue Q   +5 more
doaj