Results 21 to 30 of about 162,609 (336)
The Role of NLRP3 Inflammasomes in Trained Immunity
Frontiers in Bioscience-Landmark, 2023 Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee +3 more
doaj +1 more source
Role of NLRP3 in the pathogenesis and treatment of gout arthritis
Frontiers in Immunology, 2023 Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been attributed to a combination of genetic, environmental and metabolic factors.
Ya-ru Liu, Jie Wang, Jun Li
semanticscholar +1 more source
Autoimmunity, 2022 Osteoarthritis is thought to be a NLRP3-related disease. NEK7 is an essential mediator for NLRP3 inflammasome activation. This study aimed to demonstrate whether NEK7 has regulatory roles in the pathogenesis of osteoarthritis. C57BL/6 mice were subjected
Wei Sun +4 more
doaj +1 more source
Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]
, 2017 The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef +9 more
core +2 more sources
International Journal of Molecular Medicine, 2023 The inflammasome regulates innate immunity by serving as a signaling platform. The Nod-like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis-associated speck-like protein (ASC) and pro-caspase-1, is by far the ...
Xiaolu Zhang +9 more
semanticscholar +1 more source
Autoimmunity, 2023 Nuclear receptor subfamily 3 group C member 2 (NR3C2) has been revealed to affect the progression of multiple inflammatory diseases, while NR3C2’s efficacy in coronary artery disease (CAD) remains largely unsolved.
Xiaofan Chen +2 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Myasthenia gravis (MG) is an autoantibodies-mediated autoimmune disease with the complications of neuromuscular junction transmission. In this study, we aimed to investigate the molecular regulatory roles of pentaxin 3 (PTX3) in patients and ...
Yao Li +3 more
doaj +1 more source
Autophagy in Microglia and Alzheimer's disease [PDF]
, 2019 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core +1 more source
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
International Journal of Molecular Sciences, 2019 The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage.
N. Kelley +3 more
semanticscholar +1 more source
Expression of MAPK and inflammasomes in cells of the brain in experimental Alzheimer's disease
Анналы клинической и экспериментальной неврологии, 2017 Introduction. Alzheimer's disease is a chronic neurodegenerative disease that leads to neuropsychiatric disorders and decrease in cognitive activity.
Yana V. Gorina +4 more
doaj +1 more source