Results 11 to 20 of about 91,161 (237)

Pharmacological Inhibitors of the NLRP3 Inflammasome [PDF]

Frontiers in Immunology, 2019
Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome
Ayesha Zahid, Ayesha Zahid, Bofeng Li, Bofeng Li, Arnaud John Kombe Kombe, Tengchuan Jin, Tengchuan Jin, Tengchuan Jin, Jinhui Tao   +8 more
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The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney [PDF]

Cells, 2019
Cytoplasmic nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) forms an inflammasome with apoptosis-associated speck-like protein containing a CARD (ASC) and pro-caspase-1, which is followed by the cleavage of pro-caspase-1 to ...
Yang Gyun Kim, Su-Mi Kim, Ki-Pyo Kim, Sang-Ho Lee, Ju-Young Moon   +4 more
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Neurodegenerative Disease and the NLRP3 Inflammasome [PDF]

Frontiers in Pharmacology, 2021
The prevalence of neurodegenerative disease has increased significantly in recent years, and with a rapidly aging global population, this trend is expected to continue. These diseases are characterised by a progressive neuronal loss in the brain or peripheral nervous system, and generally involve protein aggregation, as well as metabolic abnormalities ...
Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Emily Caseley, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott   +14 more
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Targeting the NLRP3 Inflammasome in Glaucoma [PDF]

Biomolecules, 2021
Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major aetiological risk factors in glaucoma, and is currently the only modifiable risk factor. However, 30–40%
Sophie Coyle, Mohammed Naeem Khan, Melody Chemaly, Breedge Callaghan, Chelsey Doyle, Colin E. Willoughby, Sarah D. Atkinson, Meredith Gregory-Ksander, Victoria McGilligan   +8 more
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Inhibiting the NLRP3 Inflammasome [PDF]

Molecules, 2020
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy, David Brough, Sally Freeman   +2 more
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Role of the NLRP3 Inflammasome in Preeclampsia [PDF]

Frontiers in Endocrinology, 2020
Reproduction involves tightly regulated series of events and the immune system is involved in an array of reproductive processes. Disruption of well-controlled immune functions leads to infertility, placental inflammation, and numerous pregnancy complications, including preeclampsia (PE).
Koumei Shirasuna, Tadayoshi Karasawa, Masafumi Takahashi   +2 more
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NLRP3 inflammasome pathways in atherosclerosis [PDF]

Atherosclerosis, 2017
Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (
Marta Baldrighi, Xuan Li, Ziad Mallat, Ziad Mallat   +3 more
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NLRP3 inflammasome in endothelial dysfunction [PDF]

Cell Death & Disease, 2020
AbstractInflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate inflammatory responses under physiological and pathological conditions. The NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex.
Baochen Bai, Yanyan Yang, Qi Wang, Min Li, Chao Tian, Yan Liu, Lynn Htet Htet Aung, Pei-feng Li, Tao Yu, Xian-ming Chu   +9 more
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NLRP3 Inflammasome and Inflammatory Diseases [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation.
Zheng Wang, Simei Zhang, Ying Xiao, Wunai Zhang, Shuai Wu, Tao Qin, Yangyang Yue, Weikun Qian, Li Li   +8 more
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Cell Swelling and the NLRP3 Inflammasome [PDF]

Immunity, 2013
Multiple chemically and biologically diverse stimuli activate the NLRP3 inflammasome, but the precise mechanism for activation remains to be determined (Davis et al., 2011xDavis, B.K., Wen, H., and Ting, J.P.-Y. Annu. Rev. Immunol. 2011; 29: 707–735Crossref | PubMed | Scopus (433)See all ReferencesDavis et al., 2011).
Tom P. Monie, Joseph P. Boyle, Clare E. Bryant   +2 more
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