Results 11 to 20 of about 115,042 (335)
Pharmacological Inhibitors of the NLRP3 Inflammasome [PDF]
Frontiers in Immunology, 2019 Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome
Ayesha Zahid +8 more
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Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy +2 more
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NLRP3 inflammasome in endothelial dysfunction [PDF]
Cell Death & Disease, 2020 AbstractInflammasomes are a class of cytosolic protein complexes. They act as cytosolic innate immune signal receptors to sense pathogens and initiate inflammatory responses under physiological and pathological conditions. The NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex.
Baochen Bai +9 more
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DDX3X: stressing the NLRP3 inflammasome [PDF]
Cell Research, 2019 Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of pro-survival stress granules or pro-death NLRP3 ...
Daniel Fox, Si Ming Man
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Cellular localization of NLRP3 inflammasome [PDF]
Protein & Cell, 2013 AbstractInflammasome is a large protein complex activated upon cellular stress or microbial infection, which triggers maturation of pro-inflammatory cytokines interleukin-1β and interleukin-18 through caspase-1 activation. Nod-like receptor family protein 3 (NLRP3) is the most characterized inflammasome activated by various stimuli.
Yan, Wang +5 more
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NLRP3 Inflammasome and Inflammatory Diseases [PDF]
Oxidative Medicine and Cellular Longevity, 2020 Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation.
Zheng Wang +8 more
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Caging NLRP3 tames inflammasome activity
Cell, 2021 How the danger sensor NLRP3 is activated is intensively debated. Using cryo-electron microscopy (EM) approaches, Andreeva and colleagues made the remarkable discovery that inactive NLRP3 forms a double ring of 12-16 monomers that shield its pyrin domains from the cytosol. We discuss this surprising new mechanism of inflammasome regulation.
Schroder, Kate, Coll, Rebecca C
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Mechanism of NLRP3 inflammasome activation [PDF]
Annals of the New York Academy of Sciences, 2014 Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen‐ and damage‐associated molecular patterns into a proinflammatory response. This potent caspase‐1–dependent process is capable of activating the innate immune system, initiating pyroptosis (an ...
Fayyaz S, Sutterwala +2 more
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NLRP3 Inflammasome and MS/EAE [PDF]
Autoimmune Diseases, 2013 Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules.
Makoto Inoue, Mari L. Shinohara
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Targeting the NLRP3 Inflammasome in Glaucoma [PDF]
Biomolecules, 2021 Glaucoma is a group of optic neuropathies characterised by the degeneration of retinal ganglion cells, resulting in damage to the optic nerve head (ONH) and loss of vision in one or both eyes. Increased intraocular pressure (IOP) is one of the major aetiological risk factors in glaucoma, and is currently the only modifiable risk factor. However, 30–40%
Sophie Coyle +8 more
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