Results 261 to 270 of about 115,042 (335)

NEK7 accelerates NLRP3 inflammasome activation

Wöhrle S, Ćiković T, Dufossez C, Neuwirt E, Puma E, Kraatz F, Kostina A, Gorka O, Kreutz C, Groß CJ, Groß O.   +10 more
europepmc   +1 more source

NLRP3 Inflammasome: A New Target for the Treatment of CVD and Depression Comorbidity. [PDF]

Mediators Inflamm
Chen C, Zhang S, Sheng M, Shao W.
europepmc   +1 more source

Faculty Opinions recommendation of NLRP3 inflammasome activation drives tau pathology.

, 2019
Jeffrey Skolnick
openalex   +2 more sources

Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo

Nano Select, EarlyView.
A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng, Yi Yu, Mingyi Chen, Weibin Wu, Chunyan Zhu, Caisheng Wu, Weihua Li, Zehua Liu, Qiang Xie   +8 more
wiley   +1 more source

Emodin Suppresses Fluoride‐Induced Pyroptosis in SH‐SY5Y Cells Through the Inhibition of NLRP3 Inflammasome Activation [PDF]

Chencen Lai, Tai‐Bai Jiang, Tingting Xu, Taiwei Zhang, Yiyuan Zhou, Dongyang Deng, Qian Chen   +6 more
openalex   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

NLRP3 Inflammasome as Potential Predictor of Non-Responsiveness to Immunosuppressive Treatment in Lupus Nephritis. [PDF]

Int J Mol Sci
Oliveira CBL, Guaraná WL, Vajgel G, Júnior BMDS, Lima CAD, Araújo SA, Souto FO, Costa DMDN, Valente LM, Sandrin-Garcia P.   +9 more
europepmc   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

A new perspective on cancer treatment: the interaction and application prospect between ICIs and radiotherapy

Precision Radiation Oncology, EarlyView.
The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song, Lei Wang, Guopeng Zhao, Song Tan, Xin Liu, Xinghua Li   +5 more
wiley   +1 more source