Results 141 to 150 of about 217,671 (368)
A Site of Alcohol Action at the NMDA Receptor M3-M4 Domain Interface [PDF]
, 2012 The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol in the brain. Previous studies have identified positions in the third and fourth membrane-associated (M) domains of the NMDA receptor GluN1 and GluN2A subunits that influence
Dwyer, D.S +3 more
core +1 more source
PLoS ONE, 2015 Cortical neurons can respond to glutamatergic stimulation with regenerative N-Methyl-D-aspartic acid (NMDA)-spikes. NMDA-spikes were initially thought to depend on clustered synaptic activation.
Alon Poleg-Polsky
doaj +1 more source
Frontiers in Cellular Neuroscience, 2019 Transmission of excitation from L4 to L2/3 is a part of a canonical circuit of cortical sensory signal processing. While synapses from L4 to L2/3 are mediated by both AMPA and NMDA glutamate receptors, previous studies suggested that sensory-evoked ...
Julia Lebedeva +6 more
doaj +1 more source
Molecular determinants of acute kidney injury [PDF]
, 2015 BACKGROUND: Acute kidney injury (AKI) is a condition that leads to a rapid deterioration of renal function associated with impairment to maintain electrolyte and acid balance, and, if left untreated, ultimately irreversible kidney damage and renal ...
Human, Christin, Husi, Holger
core +2 more sources
Computationally Discovered Potentiating Role of Glycans on NMDA Receptors [PDF]
arXiv, 2016 N-methyl-D-aspartate receptors (NMDARs) are glycoproteins in the brain central to learning and memory. The effects of glycosylation on the structure and dynamics of NMDARs are largely unknown. In this work, we use extensive molecular dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate these effects.
arxiv
Astrocytic NMDA Receptors Modulate the Dynamics of Continuous Attractors [PDF]
arXivNeuronal networking supports complex brain functions, with neurotransmitters facilitating communication through chemical synapses. The release probability of neurotransmitters varies and is influenced by pre-synaptic neuronal activity. Recent findings suggest that blocking astrocytic N-Methyl-D-Aspartate (NMDA) receptors reduces this variation. However,
arxiv
NMDA-based pattern discrimination in a modeled cortical neuron [PDF]
, 1992 Compartmental simulations of an anatomically characterized cortical pyramidal cell were carried out to study the integrative behavior of a complex dendritic tree.
Mel, Bartlett W.
core
Combined NMDA Inhibitor Use in a Patient With Multisubstance-induced Psychotic Disorder [PDF]
, 2018 This document is an Accepted Manuscript reprinted from Journal of Addiction Medicine, Vol. 12 (3): 247-251, May 2018, with permission of Kluwer Law International. Under embargo until 1 May 2019.
Calabrò, Giuseppa +9 more
core +1 more source
Molecular Pain, 2012 Background Antidepressants, which are widely used for treatment of chronic pain, are thought to have antinociceptive effects by blockade of serotonin and noradrenaline reuptake. However, these drugs also interact with various receptors such as excitatory
Kohno Tatsuro +5 more
doaj +1 more source