Results 141 to 150 of about 240,251 (364)

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

The Impact of Lactobacillus paracasei subsp. Paracasei on Oxytetracycline‐Induced Anxiety‐Like Behavior of Zebrafish via Regulation of Gut Microbiota and Brain Fatty Acid Metabolism

Food Frontiers, EarlyView.
LPSP exhibited considerable potential in reversing OTC‐induced anxiety‐like behavior. Combined with gut microbiomics and metabolomics, we revealed the underlying mechanisms. ABSTRACT The use of oxytetracycline (OTC) in aquaculture is crucial for fish health and disease prevention, but it might accumulate in humans through the food chain, potentially ...
Yang Qiu, Jiaxin Guo, Jie Zhang, Chenxu Xue, Wanjun He, Zhenquan Huo, Jiajin Zhu   +6 more
wiley   +1 more source

Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies

Food Frontiers, EarlyView.
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue, Haitao Wen, Lian He, Yan Liu, Zeng Liang, Liyong Luo   +5 more
wiley   +1 more source

Advancements in flexible memristors for neuromorphic computing: Materials, mechanisms, and applications in synaptic emulation

FlexMat, EarlyView.
Memristors, as the fourth fundamental passive circuit element, are promising devices that can mimic synaptic functions in neural networks due to their nonlinear memory characteristics. This paper reviews recent advancements in material selection, resistive switching mechanisms, and flexible memristor architectures for artificial neural networks ...
Weiwei Li, Chunbo Duan, Ying Wei, Hui Xu
wiley   +1 more source

Neuronal THY1 Signaling Maintains Astrocytes in a Quiescent State

Glia, EarlyView.
THY1‐bearing neurons keep astrocytes in a quiescent state via the interaction with ITGB1. Depletion of THY1 supports the development of a partially activated astrocyte phenotype. Neuronal THY1 is involved in the maintenance and restoration of tissue homeostasis in the brain. ABSTRACT THY1 is a cell surface protein of mature neurons.
Juliane Loui, Ute Krügel, Ulrike Winkler, Anja Reinert, Dorit John, Johannes Hirrlinger, Anja Saalbach   +6 more
wiley   +1 more source

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Pulsed Electromagnetic Fields: A Novel Attractive Therapeutic Opportunity for Neuroprotection After Acute Cerebral Ischemia

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone, Simona Salati, Fabrizio Vincenzi, Micaela Liberti, Giorgio Aicardi, Francesca Apollonio, Katia Varani, Ruggero Cadossi, Vincenzo Di Lazzaro   +8 more
wiley   +1 more source

Selectivity and Metaplasticity in a Unified Calcium-Dependent Model [PDF]

, 2003
A unified, biophysically motivated Calcium-Dependent Learning model has been shown to account for various rate-based and spike time-dependent paradigms for inducing synaptic plasticity.
Blais, Brian S., Cooper, Leon N., Shouval, Harel Z., Yeung, Luk C.   +3 more
core   +1 more source

Recent applications of magnetic iron oxide nanoparticles for cerebral blood volume quantification in functional magnetic resonance imaging

Ibrain, EarlyView.
This study explores the recent advances in the use of iron oxide nanoparticles (IONPs) in functional MRI (fMRI) for studying brain functions, specifically cerebral blood volume (CBV) measurements. It covers fMRI techniques, magnetic nanoparticle synthesis, coating methods, and their applications in CBV imaging, in comparison to other contrast agents in
Giorgio Capuzzello, Antonella Antonelli, Rosaria Rinaldi, Riccardo Di Corato   +3 more
wiley   +1 more source