Results 231 to 240 of about 298,750 (304)
Some of the next articles are maybe not open access.
Retinogeniculate transmission by NMDA and non-NMDA receptors in the cat
Brain Research, 1991The contributions of N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino acid (EAA) receptors to retinogeniculate transmission were investigated in the cat. The EAA antagonists 2-amino-5-phosphonovaleric acid (APV) and kynurenic acid (KYN) were used to block the NMDA receptors and all EAA receptors, respectively.
K, Funke, U T, Eysel, T, FitzGibbon
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Journal of Neurochemistry, 1994
Abstract:Transient forebrain or global ischemia in rats induces selective and delayed damage of hippocampal CA1 neurons. In a previous sludy, we have shown that expression of GIuR2, the kainate/a‐amino‐3‐hydroxy‐5‐ methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit that governs Ca′ permeability, is preferentially reduced in CA1 at a time point ...
PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO +2 more
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Abstract:Transient forebrain or global ischemia in rats induces selective and delayed damage of hippocampal CA1 neurons. In a previous sludy, we have shown that expression of GIuR2, the kainate/a‐amino‐3‐hydroxy‐5‐ methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit that governs Ca′ permeability, is preferentially reduced in CA1 at a time point ...
PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO +2 more
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Alcohol, 1990
The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor.
P L, Hoffman +5 more
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The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor.
P L, Hoffman +5 more
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Current pharmaceutical design, 2019
Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes problems with memory, thinking, and behavior. Currently, there is no drug that can reduce the pathological events of this degenerative disease but symptomatic relief is ...
M. Kabir +9 more
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes problems with memory, thinking, and behavior. Currently, there is no drug that can reduce the pathological events of this degenerative disease but symptomatic relief is ...
M. Kabir +9 more
semanticscholar +1 more source
Current Opinion in Neurobiology, 2004
Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yi, Nong +2 more
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Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yi, Nong +2 more
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Synapse, 1991
AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
C, Pfeiffer-Linn, R M, Glantz
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AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
C, Pfeiffer-Linn, R M, Glantz
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NMDA receptors and schizophrenia
Current Opinion in Pharmacology, 2007The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-aspartate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic ...
Lars V, Kristiansen +3 more
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2013
?? ???????????? ?????????????????? ?????????????????????????? ?? ?????????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????????? ?????????????????????????? (???????????????????? ?
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?? ???????????? ?????????????????? ?????????????????????????? ?? ?????????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????????? ?????????????????????????? (???????????????????? ?
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NMDA retseptorsüsteemid NMDA retseptorsüsteemid
2009N-metüül-D-aspartaadi (NMDA) retseptorite kaudu toimuv kaltsiumiioonide sissevool närvirakkudesse on vajalik närvisüsteemis toimuvateks füsioloogilisteks protsessideks. Selle süsteemi üleaktivatsiooni tingimustes suureneb markantselt postsünaptilistes neuronites intratsellullarse Ca2+ hulk ning see on neuronite degeneratsiooni üks võtmeprotsesse. Selle
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Annual Review of Pharmacology and Toxicology, 2003
The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors.
Robert J, Wenthold +4 more
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The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors.
Robert J, Wenthold +4 more
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