Results 231 to 240 of about 217,671 (368)

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking. [PDF]

Neurotox Res
Karakuş F, Kuzu B.
europepmc   +1 more source

Involvement of N-rnethy1-D-aspartic acid (NMDA) receptor in the central mechanism of cough reflex

, 1990
Hideo Honda, Kazuo Takahama, Takafumi Kawaguchi, Jun-ichi Fuchikami, Hirofumi Kai, Takeshi Miyata   +5 more
openalex   +1 more source

Toward molecular phenotyping of temporal lobe epilepsy by spatial omics

Epilepsia, EarlyView.
Abstract Objective In temporal lobe epilepsy (TLE), detection of the epileptogenic zone predicts a good surgical outcome. When submitted to 18F‐fluorodeoxyglucose positron emission tomography (PET), some patients display lateralized, focal hypometabolism in the temporal lobe (PET+), whereas others appear normometabolic (PET−).
Isabeau Vermeulen, Ronny Mohren, Micca Neusinger, Tobias A. Dancker, Michiel Vandenbosch, Jan Beckervordersandforth, Benjamin Balluff, Rianna P. Van der Hel, Olaf E. M. G. Schijns, Govert Hoogland, Kim Rijkers, Berta Cillero‐Pastor, ACE epilepsy surgery group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen–Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Olaf Schijns, Ilse van Straaten, Simon Tousseyn, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +33 more
wiley   +1 more source

Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells. [PDF]

Elife
Taylor OB, DeGroff N, El-Hodiri HM, Gao C, Fischer AJ.   +4 more
europepmc   +1 more source

The contributions of NMDA, non-NMDA, and GABA receptors to postsynaptic responses in neurons of the optic tectum [PDF]

, 1993
PW Hickmott, Martha Constantine‐Paton
openalex   +1 more source

Metabolomic and proteomic stratification of equine osteoarthritis

Equine Veterinary Journal, EarlyView.
Abstract Background Equine osteoarthritis (OA) is predominantly diagnosed through clinical examination and radiography, leading to detection only after significant joint pathology. The pathogenesis of OA remains unclear and while many medications modify the disease's inflammatory components, no curative or reversal treatments exist.
James R. Anderson, Marie M. Phelan, Eva Caamaño‐Gutiérrez, Peter D. Clegg, Luis M. Rubio‐Martinez, Mandy J. Peffers   +5 more
wiley   +1 more source

An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis. [PDF]

Signal Transduct Target Ther
Vogel FCE, Schulze A.
europepmc   +1 more source

Anti-amnesic and amnesic effects of dextrorphan, an NMDA antagonist, in step-through type passive avoidance test paradigms

, 1990
Jiro Itoh, Mitsue Kurasawa, Norio Himori
openalex   +1 more source

The Sharpey‐Schafer Prize Lecture. The mechanism of induction of NMDA receptor‐dependent long‐term potentiation in the hippocampus [PDF]

, 1992
Graham L. Collingridge
openalex   +1 more source