Results 171 to 180 of about 10,005 (213)

Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD+ Biosynthesis in Whole Mice

International Journal of Molecular Sciences, 2023
Numerous efforts in basic and clinical studies have explored the potential anti-aging and health-promoting effects of NAD+-boosting compounds such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).
Anthony A Sauve, Yue Yang, Ning Zhang
exaly   +2 more sources

NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo [PDF]

Current Biology, 2017
Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically-induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth.
Andrea Loreto, Giuseppe Orsomando, Lucy F Donaldson   +2 more
exaly   +5 more sources

SS-31 and NMN: Two paths to improve metabolism and function in aged hearts [PDF]

Aging Cell, 2020
The effects of two different mitochondrial-targeted drugs, SS-31 and NMN, were tested on Old mouse hearts. After treatment with the drugs, individually or Combined, heart function was examined by echocardiography.
David J. Marcinek, Peter S. Rabinovitch, Theodor Bammler   +2 more
exaly   +2 more sources

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Deamidation of nicotinamide and NMN

Biochemical and Biophysical Research Communications, 1961
Deamidation of nicotinamide was first demonstrated in lactic acid bacteria by Hughes and Williamson (1953). Rajagopalan et al. (1958) were the first to report the presence of this enzyme nicotinamide deamidase in vertebrates. Among the vertebrates studied, the enzyme activity was exhibited only by the avian species. The present communication deals with,
Sarma, DSR, Rajalakshmi, S, Sarma, PS
openaire   +3 more sources

Purification of large neuromedin N (NMN) from canine intestine and its identification as NMN-125

Biochemical and Biophysical Research Communications, 1991
A large molecular form of neuromedin N (NMN), a neurotensin (NT)-related peptide, was purified to homogeneity from canine ileal mucosa. The amino acid sequence of its N-terminal 20 residues was found to be SDSEEEMKALEADLLTNMHT, which is identical to residues 24-43 of the cDNA-predicted NT/NMN precursor.
Robert E Carraway, S P Mitra, Sankar P Mitra   +2 more
exaly   +3 more sources

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR [PDF]

Cell Metabolism, 2018
Research on the biology of NAD+ has been gaining momentum, providing many critical insights into the pathogenesis of age-associated functional decline and diseases. In particular, two key NAD+ intermediates, nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), have been extensively studied over the past several years.
Joseph A. Baur, Jun Yoshino, Shin-Ichiro Imai   +2 more
exaly   +3 more sources

Identification of the archaeal NMN adenylyltransferase gene

Molecular and Cellular Biochemistry, 1999
Increasing evidence on the importance of fluctuations in NAD+ levels in the living cell is accumulating. Therefore a deeper knowledge on the regulation of coenzyme synthesis and recycling is required. In this context the study of NMN adenylyltransferase (EC 2.7.7.1),. a key enzyme in the NAD+ biosynthetic pathway, assumes a remarkable relevance.
Raffaelli N, Emanuelli M, Pisani F M, Amici A, Lorenzi T, Ruggieri S, Magni G   +6 more
openaire   +3 more sources

Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation

FEBS Letters, 2023
The nicotinamide adenine dinucleotide (NAD + ) precursor nicotinamide mononucleotide (NMN) is a proposed therapy for age‐related disease, whereby it is assumed that NMN is incorporated into NAD + through the canonical recycling pathway.
Lynn‐Jee Kim, Timothy J. Chalmers, Romanthi Madawala, Greg C. Smith, Catherine Li, Abhirup Das, Eric Wing Keung Poon, Jun Wang, Simon P. Tucker, David A. Sinclair, Lake‐Ee Quek, Lindsay E. Wu   +11 more
openaire   +2 more sources

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

Biosensors and Bioelectronics, 2023
Abstract Nicotinamide mononucleotide (NMN) is a major precursor for NAD + metabolism with promising effects in treating NAD + - and aging-related pathologies.
Liuqing Chen, Pei Wang, Guan Huang, Wenxiang Cheng, Kaijing Liu, Qiuliyang Yu   +5 more
openaire   +2 more sources

Anticancer action by natural ingredient NMN and its mechanism: Focusing on the molecular mechanism of NMN on breast cancer cells.

Clinical Imaging and Case Reports, 2022
It was confirmed that NMN causes a decrease in breast cancer cells. Breast cancer is now a major problem for women because it is sensitive to estrogen. The standard treatments for breast cancer are generally surgery, anticancer drugs, and radiation therapy.
openaire   +1 more source