Results 181 to 190 of about 10,005 (213)
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Exploring the De Novo NMN Biosynthesis as an Alternative Pathway to Enhance NMN Production
ACS Synthetic BiologyNicotinamide mononucleotide (NMN) serves as a precursor for NAD+ synthesis and has been shown to have positive effects on the human body. Previous research has predominantly focused on the nicotinamide phosphoribosyltransferase-mediated route (NadV-mediated route) for NMN biosynthesis.
Pengju Wang +9 more
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Recent observations on the structure and the properties of yeast NMN adenylyltransferase
Experientia, 1988A homogeneous preparation of yeast NMN adenylyltransferase (EC 2.7.7.1) showed microheterogeneity, which was revealed by FPLC (Fast Protein Liquid Chromatography) ion exchange chromatography. The resolved components have been characterized with respect to electrophoretic behavior and adenine content.
RUGGIERI, Silverio +4 more
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Modulation of Cytotoxicity of Benzamide Riboside by Expression of NMN Adenylyltransferase
Current Medicinal Chemistry, 2002Benzamide riboside (BR) is a nucleoside prodrug that is phosphorylated to its 5'-monophosphate (BRMP) and then converted to its active metabolite, BAD (benzamide adenine dinucleotide), an analogue of NAD by the action of NMN adenylyltransferase (NMNAT). BAD is a potent, reversible, and noncompetitive inhibitor of inosine 5'-monophosphate dehydrogenase (
Joel A, Yalowitz, Hiremagalur N, Jayaram
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NMN-Adenylyltransferase und NAD+-Kinase
2003Die beiden Nukleotide NAD+ und NADP+ sind essentielle Coenzyme für zahlreiche Redoxreaktionen in allen bekannten Organismen. Sie sind außerdem Vorstufen für Signalmoleküle und Substrate für kovalente Proteinmodifikationen in höheren Eukaryoten. Bislang lagen zu den essentiellen Enzymen der NAD(P)+-Synthese, der NMNAT und der NAD+-Kinase, keine ...
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NMN Synbiotics: A Multifaceted Therapeutic Approach for Alzheimer’s Disease
Neurochemical ResearchWith the aging global population, Alzheimer's disease (AD) has become a significant social and economic burden, necessitating the development of novel therapeutic strategies. This study investigates the therapeutic potential of nicotinamide mononucleotide (NMN) synbiotics, a combination of NMN, Lactiplantibacillus plantarum CGMCC 1.16089, and lactulose,
Caifeng, Li +5 more
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