Results 181 to 190 of about 17,765 (201)
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Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation
Phytomedicine, 2019Obovatol, a biphenolic chemical originating from Magnolia obovata, has been utilized as a traditional medicine for the treatment of inflammatory diseases. Inflammasome induces maturation of inflammatory cytokines in response to intracellular danger signals, and its dysregulation induces inflammatory diseases.The effect of obovatol on inflammasome ...
Jeongeun Kim +11 more
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A significant other: Non‐canonical caspase‐4/5/11 inflammasome in periodontitis
Oral Diseases, 2022AbstractPeriodontitis is an oral inflammatory disease characterised by the destruction of periodontal soft tissue and alveolar bone resorption, mainly triggered by plaque microbial infection. Pyroptosis is an inflammatory form of programmed cell death mediated by the pore‐forming gasdermin proteins, which resist the invasion of pathogens into the body ...
Zizheng Wang, Weicheng Chan, Yuan Yue
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Microglia Caspase11 non‐canonical inflammasome drives fever
Acta PhysiologicaAbstractAimAnimals exhibit physiological changes designed to eliminate the perceived danger, provoking similar symptoms of fever. However, a high‐grade fever indicates poor clinical outcomes. Caspase11 (Casp11) is involved in many inflammatory diseases. Whether Casp11 leads to fever remains unclear.
Ping Yu +6 more
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Role of Canonical and Non-canonical Inflammasomes During Burkholderia Infection
2016Burkholderia pseudomallei is a Gram-negative flagellate bacterium that causes melioidosis, a disease endemic to Southeast Asia and other tropical regions. Following infection of macrophages and other non-phagocytic cell types, B. pseudomallei or B.
Manoranjan, Sahoo +2 more
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Mechanisms of Non-canonical Inflammasome Activation by Rickettsia
The Journal of Immunology, 2016Abstract Rickettsiae are Gram-negative, obligately intracellular bacteria that infect macrophages, however, the molecular mechanisms involved in the interactions of rickettsiae with macrophages remain poorly understood. We have found that R.
Claire A Smalley +3 more
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In Vitro and In Vivo Model for Sepsis Through Non-canonical NLRP3 Inflammasome Activation
2022Sepsis is a complex disorder related to dysregulation of the host response to infection and is a major health problem worldwide owing to its high mortality rates. However, the exact mechanisms causing sepsis remains unclear because of the complexity of the underlying pathways.
Xiao, Sun, Tae-Bong, Kang, Kwang-Ho, Lee
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The dynamic and heterogeneous structure of the non-canonical inflammasome
Abstract Inflammasomes are high molecular weight complexes that play an integral role in the innate immune system, triggering an inflammatory cascade to protect against cellular stresses such as pathogenic bacteria. Both canonical and non-canonical inflammasomes have been described in the literature and detailed structural studies of ...Alexander I.M. Sever +7 more
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Archives of Biochemistry and Biophysics, 2019
The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors (PRRs) known to mediate the initial innate immune response to cellular injury and stress. The NLRP proteins represent a fourteen-member subset of the NLR family that contains an N-terminal pyrin domain. Some NLRs are known to form multi-protein complexes known as
Jaye M, Platnich, Daniel A, Muruve
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The NOD-like receptor (NLR) family of proteins is a group of pattern recognition receptors (PRRs) known to mediate the initial innate immune response to cellular injury and stress. The NLRP proteins represent a fourteen-member subset of the NLR family that contains an N-terminal pyrin domain. Some NLRs are known to form multi-protein complexes known as
Jaye M, Platnich, Daniel A, Muruve
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Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway
Toxicology and Applied Pharmacology, 2016Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and robust release of HMGB1 and pro ...
Qiu-Ru, Lin +7 more
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The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome
Immunity, 2023Pengyan Xia, Qiannv Liu, Xiwen Qin
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