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Investigating the role of the non-canonical inflammasome in senescence
2019Cellular senescence is a permanent proliferative arrest of cells triggered by several different stress mechanisms. Senescent cells display an inflammatory phenotype termed the senescence-associated secretory phenotype (SASP), being IL-1 signalling one of its key signalling pathways. Full-length IL-1b is cleaved into its mature active form by caspase-1,
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Nur77 senses LPS and dsDNA for non-canonical inflammasome activation
Nature Reviews Immunology, 2023openaire +2 more sources
Activation of the NLRP6 and non-canonical inflammasomes by bacterial pathogens
Many pathogens have evolved strategies to invade host cells to establish a replicative niche and avoid immune cell detection. However, cytosolic pattern recognition receptors can detect intracellular bacteria and induce signalling cascades leading to inflammation, immune cell recruitment and cell death to combat infection and destroy replicative nichesopenaire +1 more source
Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells
European Journal of Immunology, 2015Veit Hornung +2 more
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