Results 131 to 140 of about 10,792,655 (300)

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

Human leukocyte antigen-associated uveitis in Thai population: Brief review

Journal of Associated Medical Sciences, 2015
Human Leukocyte Antigen (HLA) has been associated with several immune-mediated diseases, malignancies and infectious diseases. Due to the HLA complexity and polymorphisms, several types of HLA have been used as the molecular markers in diagnosis.
Nampeung Anukul, Nipapan Leetrakool, Kessara Pathanapitoon   +2 more
doaj  

Recognition of the new HLA-DQB1*06 variant, HLA-DQB1*06:03:41, in a Russian individual

, 2021
One nucleotide substitution in codon 174 of HLA-DQB1*06:03:01:01 results in a novel allele, HLA-DQB1*06:03 ...
Shagimardanova E., Leksina Y., Ananeva A., Gusev O.   +3 more
core  

Fine‐scale genetic structure of the cloud forest tree Ocotea psychotrioides revealed by genome‐wide SNP data

American Journal of Botany, EarlyView.
Abstract Premise Recent advances in genomic technologies now enable the reconstruction of evolutionary histories at fine spatial scales, illuminating the complex dynamics that shape biodiversity patterns in naturally discontinuous, archipelago‐like ecosystems such as cloud forests.
Leopoldo Hurtado‐Reveles, Lidia I. Cabrera, Juan Francisco Ornelas, Santiago Ramírez‐Barahona, Andrés Ernesto Ortiz‐Rodriguez   +4 more
wiley   +1 more source

A computational HLA allele-typing protocol to de-noise and leverage nanopore amplicon data

BMC Genomics
Background Rapid turnaround time for a third-field resolution deceased donor human leukocyte antigen (HLA) typing is critical to improve organ transplantation outcomes.
Jalal Siddiqui, Rohita Sinha, James Grantham, Ronnie LaCombe, Judith R. Alonzo, Scott Cowden, Steven Kleiboeker   +6 more
doaj   +1 more source

Immune suppression, HLA-risk and potential future immune based targets of oral leukoplakia progression

Frontiers in Dental Medicine
BackgroundOral leukoplakia (OL) is the most common oral potentially malignant disorder and carries a non-trivial risk of malignant transformation. Biomarkers are sought to aid in identifying lesions with high risk for malignant transformation, yet none ...
Mehar Soni, Bryce DeSantis, Alessandro Villa, Malek Kamoun, James Gates   +4 more
doaj   +1 more source

HLA-B*5701 screening for hypersensitivity to Abacavir [PDF]

, 2008
Background Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to ...
Jagel-Guedes, E., Kozyrev, O., Phillips, E., Fitch, N., Thorborn, D., Molina, J-M, Hughes, A., Cid, J.F., Rugina, S., Nolan, D., Carosi, G., Hay, P., Ryan, S., Tomazic, J., Hughes, S., Benbow, A., Mallal, S., Workman, C.   +17 more
core  

Distinct Consequences of BCOR and BCORL1 Mutations in Myeloid Neoplasms and Bone Marrow Failure

American Journal of Hematology, EarlyView.
ABSTRACT BCOR and BCORL1 (BCOR/L1) mutations are observed in both myeloid neoplasms (MN) and bone marrow failure syndromes (BMF), but their clinical significance may differ. We analyzed 11 340 patients and identified 418 BCOR/L1‐mutated patients, focusing on differences between MN and BMF. Compared with MN, BMF was associated with younger age, a higher
Atsushi Marumo, Arda Durmaz, Christopher Haddad, Aashray Mandala, Felipe de Almeida Sartori, Akram Abushamma, Serhan Unlu, Xiaorong Gu, Zachary Brady, Matteo D'Addona, Kartik Lakhotiya, Luca Guarnera, Masanori Yoshida, Monika M. Toma, Mark D. Orland, Carlos Bravo‐Perez, Carmelo Gurnari, Koichi Takahashi, Tomasz Skorski, Stephan Hutter, Torsten Haferlach, Marcin Wlodarski, Valeria Visconte, Jaroslaw P. Maciejewski   +23 more
wiley   +1 more source

DE NOVO ANTI HLA ANTIBODIES AFTER KIDNEY TRANSPLANTATION: CLINICAL SIGNIFICANCE AND ASSOCIATION WITH GRAFT FUNCTION [PDF]

Archives of the Balkan Medical Union, 2017
Background. Kidney transplantation (TR) is the best treatment of chronic kidney disease. Chronic cellular and antibody mediated rejections have still major impact on graft survival.
Galina Severova, Igor Nikolov, Koco Cakalaroski, Aleksandar Sikole, Lada Trajceska, Goce Spasovski, Kocho Dimitrovski, Irena Rambabova Busljetic, Ninoslav Ivanovski   +8 more
doaj  

Characterisation of HLA-specific antibodies [PDF]

A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the ...
Lowe, David Philip
core