Results 121 to 130 of about 10,792,655 (300)

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

The HLA-B*58:01:43 allele identified in a Korean individual awaiting hematopoietic stem cell transplant

HLA-B*58:01:43 differs from HLA-B*58:01:01:01 by one synonymous nucleotide substitution in codon ...
John Jeongseok Yang, Heung-Bum Oh
core   +1 more source

Abacavir and the altered peptide repertoire model: Clinical implications [PDF]

, 2012
Structural and biochemical studies showing that abacavir binds non-covalently to the floor of the peptide binding groove of HLAB* 5701 with exquisite specificity to alter the self-peptides that load on the molecule to be presented to the immune system ...
Phillips, E., Mallal, S.
core  

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

Mapping the Landscape of Host-Pathogen Coevolution: HLA Class I Binding and Its Relationship with Evolutionary Conservation in Human and Viral Proteins [PDF]

, 2011
The high diversity of HLA binding preferences has been driven by the sequence diversity of short segments of relevant pathogenic proteins presented by HLA molecules to the immune system.
Jojic, N., Hertz, T., Nolan, D., John, M., Gaudieri, S., Phillips, E.J., James, I., Huang, J.C., Riadi, G., Mallal, S.   +9 more
core  

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

Identification of multiple novel HIV-specific T-cell epitopes using HLA-associated HIV polymorphisms [PDF]

, 2009
HIV adapts to T-cell immunity by mutating within or near HLA-restricted CD8-T cell epitopes and therefore HLA allele-specific HIV polymorphisms in a human population mark the immunogenic targets of CD8 T-cell responses relevant to that population in-vivo.
McKinnon, E., Chopra, A., Roberts, S., John, M., Almeida, C., Keane, N.M., Keane, N., Cooper, D., Heckerman, D., Roberts, S.G., Corkery, M., Bronke, C., James, I., Ahmad, I., Mallal, S.   +14 more
core  

HLA-H, HLA-A and HLA-G signal sequence alignment. Variable amino-acid positions among loci are highlighted in bold.

, 2016
HLA-H, HLA-A and HLA-G signal sequence alignment. Variable amino-acid positions among loci are highlighted in bold.
Julie Di Cristofaro (473988), Jacques Chiaroni (473993), Audrey Tous (3192987), Stéphane Buhler (149592), Virginia Ferreira (3192984), Céline René (10829), Jean-François Eliaou (273686), Federico Carlini (501365), Christophe Picard (501369)   +8 more
core   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

Advanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He, Han Xu, Julian M. M. Rogasch, Nikolaus Berndt, Jing Guo, Eyk Schellenberger, Akvile Häckel, Luisa Heidemann, Friederike Hesse, Yu Liu, Justus Ramtke, Nicola Beindorff, Frank Hofheinz, Avan Kader, Michael Mülleder, Kathrin Textoris‐Taube, Bernd Hamm, Dominik N. Müller, Robin Schmidt, Ralf Hauptmann, Heike Traub, Mathias Schannor, Lynn Jeanette Savic   +22 more
wiley   +1 more source

A new allele found in a volunteer hematopoietic stem cell donor : HLA-B*15:465

, 2019
HLA-B*15:465 differs from HLA-B*15:01:01:01 in codon 336 of exon 7.
Bengtsson, Mats,, Mats Bengtsson, Carina Knutson, Anders Hedin, Hedin, Anders,, Knutson, Carina,   +5 more
core   +1 more source