Results 101 to 110 of about 10,792,655 (300)

Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset

Frontiers in Immunology
IntroductionType 1 diabetes is an autoimmune disease with an significant genetic component, played mainly by the HLA class II genes. Although evidence on the role of HLA class I genes in developing type 1 diabetes and its onset have emerged, current HLA ...
Antonietta Robino, Elena Bevilacqua, Luana Aldegheri, Andrea Conti, Valentina Bazzo, Gianluca Tornese, Gianluca Tornese, Eulalia Catamo   +7 more
doaj   +1 more source

Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein [PDF]

, 2001
The BCR-ABL oncogene is central in the pathogenesis of chronic myeloid leukemia (CML). Here, tandem nanospray mass spectrometry was used to demonstrate cell surface HLA- associated expression of the BCR-ABL peptide KQSSKALQR on class I-negative CIVIL ...
Lill, JR, Christmas, SE, Wang, LH, Macintyre, AR, Bourdon, A, Hill, SC, Rojas, J, Dodi, IA, Bonner, PLR, Aubert, G, Creaser, CS, Clark, RE, Rees, RC, Travers, PJ, Madrigal, JA   +14 more
core   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis

, 2004
In order to analyze whether loci in the human leukocyte antigen (HLA) class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis (MS), we examined selected microsatellite markers in 177 Nordic sib-pair ...
K.-M. Myhr, Fredrikson, S, A. Spurkland, Celius, EG, Dai, KZ, L.P. Ryder, E.G. Celius, Mellgren, SI, F. Vartdal, K.-Z. Dai, Lorentzen, AR, M. Laaksonen, Vartdal, F, H.F. Harbo, A. Svejgaard, A. Edland, Andersen, O, J. Hillert, Nyland, H, A. Compston, S. Fredrikson, Hillert, J, P.S. Sorensen, H. Nyland, Sawcer, S, Spurkland, A, Edland, A, Oturai, A, B.A. Lie, O. Andersen, A.R. Lorentzen, Lie, BA, S. Sawcer, Myhr, KM, Sorensen, PS, M. Sandberg-Wollheim, S.I. Mellgren, Laaksonen, M, Compston, A, Harbo, HF, A. Oturai, Svejgaard, A, Ryder, LP, Lorentzen, Å, Hillert, J,, Sandberg Wollheim, Magnhild,, Lund University.   +46 more
core   +1 more source

Presence of an expressed 13-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction [PDF]

, 1994
An expressed beta-tubulin gene (TUBB) has previously been localized to chromosome region 6pter-p21 in man. By using a panel of deletion mutant cell lines and radiation-reduced hybrids containing fragments of chromosome 6, the TUBB locus could be mapped ...
Trowsdale, John, Volz, Armin, Ziegler, Andreas, Weiss, Elisabeth H.   +3 more
core   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers [PDF]

, 2012
Background and Aims: Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV ...
Stefan Zeuzem, Jörn Lötsch, Doehring, Alexandra, Vermehren, Johannes, Alexandra Doehring, Susser, Simone, Annemarie Berger, Sarrazin, Christoph, Sabine Wicker, Berger, Annemarie, Lötsch, Jörn, Christoph Sarrazin, Johannes Vermehren, Wicker, Sabine, Simone Susser, Zeuzem, Stefan, Berger Annemarie, Doehring Alexandra, Sarrazin Christoph, Lötsch Jörn, Susser Simone, Zeuzem Stefan, Vermehren Johannes, Wicker Sabine   +23 more
core   +2 more sources

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Weber, R., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Freitas, Elizabeth, H. Furrer, Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Mallal, S.A., James, I., Gaudieri, Silvana, Park, Lawrence P., Mallal, S. A., Mallal, Simon A., Park, L. P.   +57 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source