Results 111 to 120 of about 10,792,655 (300)
The novel HLA-A*02:941 allele was identified during high-resolution HLA typing
, 2021 HLA-A*02:941 has one synonymous nucleotide change from HLA-A*02:07:01 at nucleotide ...
Andryushkina A. +3 more
core
CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells
Advanced Science, EarlyView.AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu +6 more
wiley +1 more source
Current OncologyHLA-matched allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many patients. Unrelated HLA-matched donors are the most frequently used donor for HCT.
Gaganvir Parmar +5 more
doaj +1 more source
New aspects of spondyloarthritis pathogenesis. Part I. Genetic factors and role of HLA-B27 molecules
Rheumatology, 2014 Recent data verify understanding of spondyloarthritis (SpA) pathogenesis by showing that there is the overlap between traditionally classified subtypes in terms of genetic background (HLA-B27 alleles, variants of IL-23R, ERAP1 and ERAP2 genes), which is ...
Ewa Kontny
doaj +1 more source
Advanced Science, EarlyView.Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana +19 more
wiley +1 more source
Advanced Science, EarlyView.Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li +15 more
wiley +1 more source
Advanced Science, EarlyView.Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin +6 more
wiley +1 more source
Advanced Science, EarlyView.Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou +13 more
wiley +1 more source
Identification of the Novel HLA-DQB1*06:432 Allele by Sequence-Based Typing
HLA-DQB1*06:432 differs from HLA-DQB1*06:09:01:01 by a nonsynonymous nucleotide substitution in codon 186, changing Valine to ...
John Jeongseok Yang, Heung-Bum Oh
core +1 more source
Summary of free HLA, free TCR and the various p-HLA and p-HLA-TCR complexes during MD trajectories.
, 2016 Summary of free HLA, free TCR and the various p-HLA and p-HLA-TCR complexes during MD trajectories.
José Antonio Pérez-Simón (510830) +5 more
core +1 more source