Results 91 to 100 of about 1,110,814 (176)

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. [PDF]

, 2019
Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory elements in the non-coding genome, but off-target effects in these experiments have not been systematically evaluated.
Aradhana, Bassik, Michael C, Bintu, Lacramioara, Ego, Braeden K, Greenleaf, William J, Greenside, Peyton G, Hess, Gaelen T, Kaplow, Irene M, Kundaje, Anshul, Li, Amy, Marinov, Georgi K, Morgens, David W, Phanstiel, Douglas H, Snyder, Michael P, Spees, Kaitlyn, Trevino, Alexandro E, Truong, Alisa, Tycko, Josh, Ursu, Oana, Wainberg, Michael, Yao, David   +20 more
core  

Advancing PFASs monitoring in food: from targeted SPE-LC-MS/MS to non-targeted QuEChERS-LC-HRMS approaches

Food Chemistry: X
Per- and polyfluoroalkyl substances (PFASs) are increasingly recognized as emerging contaminants, with some classified as persistent organic pollutants (POPs) and four recently regulated in food in the EU.
Cassandre Jeannot, Nicolas Macorps, Bruno Le Bizec, Julien Parinet, Gaud Dervilly   +4 more
doaj   +1 more source

Identification of Differential Metabolites in Chronic Suppurative Otitis Media With Non‐Targeted and Targeted Metabolomics Approach

Smart Medicine
Chronic suppurative otitis media (CSOM) is a leading cause of hearing loss and otorrhea, and when associated with cholesteatoma, it can pose a serious threat to patients' lives.
Lidan Hu, Yifan Zhu, Chengpeng Wu, Xiao Liu, Qi Wang, Yangyiyi Huang, Hongyan Liu, Xiangjun Chen, Wei Wu, Hua Jiang   +9 more
doaj   +1 more source

Health Savings Account - Eligible High Deductible Health Plans: Updating the Definition of Prevention [PDF]

, 2014
High-deductible health plans (HDHPs) are an important and growing part of the health insurance landscape. By some estimates, as many as 80 percent of large employers may offer an HDHP in 2014.
A. Mark Fendrick, Elizabeth Q. Cliff, Kaden Milkovich, Kathryn Spangler, M. Richard McKellar, Michael Chernew, Stephen Parents   +6 more
core  

Non-targeted screening and toxicity study of safety risk substances in facial skincare products: Molecular networking and computational toxicology strategy

Journal of Dermatologic Science and Cosmetic Technology
Background: Risk substances in cosmetics have long been associated with adverse reactions. However, as risk substances become more concealed and diversified, conventional targeted analysis methods are no longer sufficient to meet regulatory requirements.
Dong Guo, Yaxiong Liu, Jingwen Liang, Yayang Huang, Yangjie Li, Jihui Fang, Sheng Yin   +6 more
doaj   +1 more source

A targeted gene panel that covers coding, non-coding and short tandem repeat regions improves the diagnosis of patients with neurodegenerative diseases [PDF]

, 2019
Genetic testing for neurodegenerative diseases (NDs) is highly challenging because of genetic heterogeneity and overlapping manifestations. Targeted-gene panels (TGPs), coupled with next-generation sequencing (NGS), can facilitate the profiling of a ...
Au, Wing Chi, Chan, Anne Yin-Yan, Chan, Ho Yin Edwin, Chan, Larry W L, Chan, Ting-Fung, Cheng, Timothy H T, Li, Jing-Woei, Lin, Xiao, Mok, Vincent C T, Yim, Aldrin Kay-Yuen, Yu, Allen Chi-Shing, Yuen, Liz Y P   +11 more
core   +1 more source

Non-Targeted Screening of Metabolites in Aqueous-Ethanol Extract from Spiraea hypericifolia (Rosaceae) Using LC-HRMS. [PDF]

Int J Mol Sci, 2023
Kostikova VA, Petrova NV, Shaldaeva TM, Koval VV, Chernonosov AA.   +4 more
europepmc   +1 more source

Screening sites for detection of carbapenemase-producers– a retrospective cohort study

Antimicrobial Resistance and Infection Control
While screening the rectal site and urine may be appropriate for detection of carbapenemase-producing Enterobacterales, respiratory samples, throat and wound swabs may increase the sensitivity of screening protocols when aiming to detect colonization ...
Isabelle Vock, Silvio Ragozzino, Pascal Urwyler, Michelle Baumann, Gioele Capoferri, Peter M. Keller, Sarah Tschudin-Sutter   +6 more
doaj   +1 more source

Non-targeted screening and characterization of organic pollutants in wastewater from an industrial park in China

Emerging Contaminants
Industrial parks are significant sources of complex water pollution, making it challenging to trace pollutant origins and ensure water quality. This study established a non-targeted screening workflow and compound persistence, mobility, and toxicity (PMT)
Xu Tan, Shanwei Sun, Song Hou, Linlin Wu, Yangwei Bai, Hongbo Xi, Jian Xu, Changsheng Guo   +7 more
doaj   +1 more source

Non-target screening and environmental specimen banking: French perspectives

, 2017
In 2016, French regulatory bodies launched a new and ambitious monitoring program so called “prospective monitoring network”, in view of improving and promoting knowledge acquired about the occurrence of contaminants in water environments. Among various actions supported by this program, a specific one is focused on non-target screening strategies.
Togola, Anne, Lardy Fontan, S., Lestremau, Francois, Margoum, Christelle   +3 more
openaire   +1 more source