Results 61 to 70 of about 1,110,814 (176)

Targeted pharmacotherapy after somatic cancer mutation screening [version 2; referees: 2 approved]

F1000Research, 2016
Many patients with solid tumours are treated with targeted pharmacotherapy based on the results of genetic testing (‘precision medicine’). This study investigated the use of targeted drugs after OncoFOCUS™+KIT screening in patients with malignant ...
Thomas M. Polasek, Karen Ambler, Hamish S. Scott, Michael J. Sorich, Peter A. Kaub, Andrew Rowland, Michael D. Wiese, Ganessan Kichenadasse   +7 more
doaj   +1 more source

Honey Phenolic Compound Profiling and Authenticity Assessment Using HRMS Targeted and Untargeted Metabolomics

Molecules, 2021
Honey consumption is attributed to potentially advantageous effects on human health due to its antioxidant capacity as well as anti-inflammatory and antimicrobial activity, which are mainly related to phenolic compound content.
Georgios A. Koulis, Aristeidis S. Tsagkaris, Reza Aalizadeh, Marilena E. Dasenaki, Eleni I. Panagopoulou, Spyros Drivelos, Michał Halagarda, Constantinos A. Georgiou, Charalampos Proestos, Nikolaos S. Thomaidis   +9 more
doaj   +1 more source

The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice. [PDF]

, 2015
BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease.
A Chauffard, A Vickers, AD Hingorani, Adam Timmis, AJ Vickers, Alastair D Hay, C Mar Del, CK Lee, DA Asch, Danielle A Van Der Windt, DE Newby, Douglas G Altman, E Rosenberg Charles, E Stolper, EAM Gale, EW Steyerberg, G-J Dinant, George Peat, H Downing, H Hemingway, Harry Hemingway, HG Welch, HM Krumholz, I Roberts, Ian Roberts, Independent UK Panel on Breast Cancer Screening, J Vestbo, J Wellwood, JC Hill, JG Jarvik, Jonathan J Deeks, Jutel Annemarie Goldstein, Kate M Dunn, L Ferrante di Ruffano, Linda LeResche, M Korff Von, M Roland, Michael Sharpe, Michael Von Korff, O Bruder, P Brown, Pablo Perel, PD White, Peter Croft, PM Bossuyt, R Aronowitz, R Moynihan, R Smith-Bindman, RA Aronowitz, Richard D Riley, Richard J Stevens, RK Simmons, RO Bonow, SJ Lord, SS Watson, Steffen E Petersen, TB Murdoch, WJ Katon   +57 more
core   +4 more sources

Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation [PDF]

, 2018
Sounds associated with newly learned information that are replayed during non-rapid eye movement (NREM) sleep can improve recall in simple tasks. The mechanism for this improvement is presumed to be reactivation of the newly learned memory during sleep ...
Diana M. Armstrong, Lexus T. Hernandez, Mario Aguilar, Michael P. Weisend, Nicola Cellini, Nicola Cellini, Patrick M. Connolly, Renee E. Shimizu, Rolando Estrada, Sara C. Mednick, Stephen B. Simons   +10 more
core   +2 more sources

Cyanoacetohydrazide as a Novel Derivatization Agent for the Determination of UHPLC-HRMS Steroids in Urine

Molecules
The possibility of cyanoacetohydrazide usage as a novel derivatizing agent is demonstrated in the presented article, and a comparison with hydroxylamine as the most commonly used reagent is provided.
Azamat Temerdashev, Maria Zorina, Yu-Qi Feng, Elina Gashimova, Victor V. Dotsenko, Vitalij Ioutsi, Sanka N. Atapattu   +6 more
doaj   +1 more source

Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS)

Toxins, 2018
When considering the geographical expansion of marine toxins, the emergence of new toxins and the associated risk for human health, there is urgent need for versatile and efficient analytical methods that are able to detect a range, as wide as possible ...
Inès Dom, Ronel Biré, Vincent Hort, Gwenaëlle Lavison-Bompard, Marina Nicolas, Thierry Guérin   +5 more
doaj   +1 more source

Expanded Carrier Screening in Chinese Population – A Survey on Views and Acceptance of Pregnant and Non-Pregnant Women

Frontiers in Genetics, 2020
ObjectiveRecessive genetic diseases impose physical and psychological impacts to both newborns and parents who may not be aware of being carriers. Expanded carrier screening (ECS) allows screening for multiple genetic conditions at the same time. Whether
Hiu Yee Heidi Cheng, Grace Ching Yin Wong, Yuen-Kwong Kelvin Chan, Chin Peng Lee, Mary Hoi Yin Tang, Ernest Hung-Yu Ng, Anita Sik-Yau Kan   +6 more
doaj   +1 more source

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis [PDF]

, 2016
Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the Retinoblastoma 1 (RB1) gene is the initiating genetic lesion. Although recently curative rates of retinoblastoma have increased, there are at this time no molecular targeted ...
Boel, Annekatrien, Colpaert, Robin, Creytens, David, Deforce, Dieter, Dimitrakopoulou, Dionysia, Haustraete, Jurgen, L, J, Lepez, Trees, Naert, Thomas, Steyaert, Wouter, Van Nieuwenhuysen, Tom, Vleminckx, Kris, Willaert, Andy   +12 more
core   +2 more sources

Strategy to improve the confidence level of qualitative screening by high resolution mass spectrometry: A case study of mycotoxins in maize

Food Chemistry: X
Targeted, suspect and non-targeted screening by high-resolution mass spectrometry (HRMS) is developing rapidly. In this study, a qualitative screening method was established using HPLC-HRMS on data dependent acquisition for the analysis of mycotoxins in ...
Yan Gao, Mengyu Feng, Xiuqin Li, Yan Zhang, Jinglei Hu, Kangcong Li, Jianhua Duan, Qinghe Zhang   +7 more
doaj   +1 more source

An improved PCR strategy for fast screening of specific and random integrations in rAAV-mediated gene targeted cell clones

BMC Research Notes, 2011
Background Gene targeting by homologous recombination using recombinant adeno-associated virus (rAAV) is becoming a useful tool for basic research and therapeutic applications due to the remarkably high targeting frequency of rAAV virus vectors. However,
Sørensen Charlotte B, Bolund Lars, Luo Yonglun   +2 more
doaj   +1 more source