Results 51 to 60 of about 333,820 (286)

Spectral-element modeling of spontaneous earthquake rupture on rate and state faults: Effect of velocity-strengthening friction at shallow depths [PDF]

, 2008
We develop a spectral-element methodology (SEM) for simulating dynamic rupture on rate and state faults and use it to study how the rupture is affected by a shallow fault region of steady-state velocity-strengthening friction.
Ampuero, J.-P., Kaneko, Y., Lapusta, N.
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Heterogeneous aging in spin glasses

, 2002
We introduce a set of theoretical ideas that form the basis for an analytical framework capable of describing nonequilibrium dynamics in glassy systems. We test the resulting scenario by comparing its predictions with numerical simulations of short-range
A. Barrat, A. Barrat, A. Barrat, A. van Blaaderen, C. Bennemann, Claudio Chamon, D. S. Fisher, E. Marinari, E. R. Weeks, E. Vidal-Russell, E. Vincent, F. Ricci-Tersenghi, H. Makse, Horacio E. Castillo, J-L Barrat, J-L. Barrat, J-P Bouchaud, L. Bellon, L. C. E. Struick, L. F. Cugliandolo, L. F. Cugliandolo, L. F. Cugliandolo, Leticia F. Cugliandolo, M. D. Ediger, M. Picco, Malcolm P. Kennett, P. H. Poole, S. Franz, T. S. Grigera, W. K. Kegel, W. Kob, W. Kob   +31 more
core   +1 more source

How Non-Uniform Temperatures Influence the Performance and Ageing of Lithium-Ion Batteries

, 2021
Lithium-Ionen Batterien (LIB) finden aufgrund ihrer Vorteile hinsichtlich Energie- und Leistungsdichte sowie ihrer Zuverlässigkeit verbreitete An-wendung als elektrochemische Energiespeicher. Sie spielen im Rahmen des Klimawandels und der dadurch bedingten Energiewende eine zentrale Rolle in der Elektrifizierung der Mobilität.
openaire   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Study on the Electroacoustic Pulse Method for Space Charge Recovery Algorithm Considering Temperature Gradient Aging

Energies
This study addresses the impact of temperature gradient-induced non-uniform aging on the accuracy of space charge measurements in cross-linked polyethylene (XLPE) insulation for high-voltage direct-current cables.
Jia Chu, Yanqing Li, Heng Yang, Tao Han
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Nonequilibrium dynamics of random field Ising spin chains: exact results via real space RG

, 2000
Non-equilibrium dynamics of classical random Ising spin chains are studied using asymptotically exact real space renormalization group. Specifically the random field Ising model with and without an applied field (and the Ising spin glass (SG) in a field),
A. Barrat, A. Vilenkin, A.D. Rutenberg, A.J. Bray, A.J. Bray, A.J. Bray, A.J. Bray, A.O. Golosov, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Derrida, C. Dasgupta, C. Godreche, C. Monthus, Cécile Monthus, D.S. Fisher, D.S. Fisher, D.S. Fisher, D.S. Fisher, D.S. Fisher, D.S. Fisher, D.S. Fisher, D.S. Fisher, Daniel S. Fisher, E. Farhi, E. Gardner, E. Vincent, G. Grinstein, I Morgenstern, J. Bene, J.M. Luck, L. Berthier, L.F. Cugliandolo, L.F. Cugliandolo, L.F. Cugliandolo, M. Puma, M. Weigt, O. Motrunich, P. Le Doussal, P. Le Doussal, P.L. Krapivsky, Pierre Le Doussal, R. Bruinsma, R.A. Hyman, S.N. Majumdar, S.R. Anderson, T. Nattermann, U. Brandt, Y.G. Sinai   +52 more
core   +3 more sources

Simulating Electron Transport and Synchrotron Emission in Radio Galaxies: Shock Acceleration and Synchrotron Aging in Axis-Symmetric Flows [PDF]

, 1998
We introduce a simple and economical but effective method for including relativistic electron transport in multi-dimensional simulations of radio galaxies. The method is designed to follow explicitly diffusive acceleration at shocks, and, in smooth flows
Andrew Engel, Berezhko E., Coleman C. S., Dennett-Thorpe J., Dongsu Ryu, Drury L., Ellison D. C., Falle S. A. E. G., Grappin R., Heavens A. F., Jaffe W. J., Kang H., Kardashev N. S., Krulls W. M., Lagage P. O., Leahy J. P., Lee M. A., Levinson A., Mack K.-H., Matthews A. P., Meisenheimer K., Ryu D., Skilling J., T. W. Jones, Takarada K., Weiss N. O.   +25 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source