Results 71 to 80 of about 131,930 (291)

Successful aging: considering non-biomedical constructs

, 2016
Lisa F Carver,1 Diane Buchanan2 1Department of Sociology, Queen’s University Kingston, ON, Canada; 2School of Nursing, Queen’s University Kingston, ON, Canada Objectives: Successful aging continues to be applied in a variety of contexts and
Buchanan D, Carver LF
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Characterization of long-term field aging: differential impacts on rheological, chemical, and morphological properties of binders across the lanes of flexible pavement

International Journal of Transportation Science and Technology
Field aging is a complicated process wherein the binder ages inevitably due to the synergic effects of temperature, humidity, pressure, ultraviolet (UV) rays, and oxidation that occur in the field, and has a significant impact on the service life of ...
S. Tejeshwini, K.H. Mamatha, S.V. Dinesh
doaj   +1 more source

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]

, 2012
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N, Lang, Pierre-Olivier, Govind, Sheila, Aspinall R, Mendes A, Mendes, Aline, Socquet, Jennifer, Govind S, Socquet J, Assir, Noémie, Lang PO, Aspinall, Richard   +11 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Influence of Relative Humidity and Aging on Morphology and Chemical Composition on Biomass Burning Particle

Aerosol and Air Quality Research
Agricultural waste burning is a major source of fine particulate matter (FPM), which remains in long-term suspension in the atmosphere during the aging processes.
Titinan Utavong, Thunyapat Thongyen, Surat Bualert, Parkpoom Choomanee, Saranarat Kongkeaw, Tanawan Rattanapotanan, Jitlada Phupijit, Suteekan Maneejantra, Nitchakarn Changplaiy   +8 more
doaj   +1 more source

Potential of strain-integrated gas infusion (SIGI) casting on post-heat treatment kinetics of AZ91 magnesium alloy

Journal of Magnesium and Alloys
Heat treatments play a crucial role in enhancing the mechanical properties of AZ91 Mg alloy by dissolving coarse phases during solution treatment and promoting precipitation during aging.
V. Tiwari, S.K. Panigrahi
doaj   +1 more source

Quantification of Damage Progression in a Thermally Aged Duplex Stainless Steel

Materials Research, 2002
Ferrite of austeno-ferritic stainless steels maintained for a long time at temperatures in the range of 270 °C to 400 °C is embrittled like the known 475 °C embrittlement of ferritic stainless steels.
A. Hazarabedian, B. Marini
doaj   +1 more source

Editorial: Somatic mutations, genome mosaicism and aging

, 2023
We present a Research Topic entitled “Somatic mutations, genome mosaicism, and aging” in Frontiers in Aging. Somatic mutations are defined as mutations that occur in cells of the body after fertilization.
Lodato, Michael A, Vijg, Jan
core   +1 more source