Results 71 to 80 of about 88,367 (250)

Enhancing mechanical properties of wire + arc additively manufactured INCONEL 718 superalloy through in-process thermomechanical processing

Materials & Design, 2018
Wire + arc additive manufacture (WAAM) was applied to produce INCONEL 718 superalloy (IN718) components in a layer by layer manner; further, interpass cold rolling was introduced to generate in-process thermomechanical processing effect during the ...
Xiangfang Xu, Supriyo Ganguly, Jialuo Ding, Cui Er Seow, Stewart Williams   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Hippocampal iron patterns in aging and mild cognitive impairment

Frontiers in Aging Neuroscience
IntroductionThe entorhinal cortex (EC)-hippocampus system is critical for memory and affected early in Alzheimer’s disease (AD). Cognitive dysfunction in AD is linked to neuropathological changes, including non-heme iron accumulation in vulnerable brain ...
Sonja M. Kagerer, Sonja M. Kagerer, Sonja M. Kagerer, Laetitia Vionnet, Jiri M. G. van Bergen, Rafael Meyer, Anton F. Gietl, Anton F. Gietl, Klaas P. Pruessmann, Christoph Hock, Christoph Hock, Paul G. Unschuld, Paul G. Unschuld   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Editorial: Tendon Structure-Function Relationship in Health, Ageing, and Injury

Frontiers in Sports and Active Living, 2021
Huub Maas, Toni Arndt, Jason R. Franz
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity

Immunity & Ageing
Background As individuals age, the immune system undergoes complex changes, including an increase in the number of CD8 T cells relative to CD4 T cells, a decline in naïve cell production (including T and B cells), and an accumulation of terminally ...
Kate A. Duchowny, Yuan S. Zhang, Rebecca C. Stebbins, Xin Ma, Jaydon Jun Yu Chin, Virginia W. Chang, Allison E. Aiello, Grace A. Noppert   +7 more
doaj   +1 more source

Aging Exacerbates Restraint Stress-Induced Inhibition of Antigen-Specific Antibody Production in Mice

Allergology International, 2009
Background: We have recently found that exposure to acute restraint stress suppresses antigen-specific antibody production, including IgE, in a murine model of allergic rhinitis.
Yumiko Ichihara, Mitsuhiro Okano, Keiko Nishioka, Noriko Manabe, Naoto Ichihara, Fumihiko Jitsunari, Tazuko Fujiwara, Kazunori Nishizaki   +7 more
doaj   +1 more source