Ferroptosis: Therapeutic Potential and Strategies in Non-Small Cell Lung Cancer
BiologyNon-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and a leading cause of cancer-related morbidity and mortality worldwide. Despite advancements in therapeutic strategies, the prognosis for NSCLC patients remains unfavorable ...
Ying Lei +4 more
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An Investigation of RNA Methylations with Biophysical Approaches in a Cervical Cancer Cell Model
CellsRNA methylation adds a second layer of genetic information that dictates the post-transcriptional fate of RNAs. Although various methods exist that enable the analysis of RNA methylation in a site-specific or transcriptome-wide manner, whether ...
Buket Sağlam +5 more
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MoleculesCardiovascular diseases (CVDs) represent a leading global health crisis, significantly impairing patients’ quality of life and posing substantial risks to their survival.
Qian Chen +3 more
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Debao Wang, the founder of nucleic acid biology and industry in People’s Republic of China
Protein & Cell, 2020 Zhongliang Ma, Xianyi Wang, Yanli Li
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Identification and Analysis of Sex-Biased Copy Number Alterations
Health Data ScienceBackground: Sex difference has long been recognized at cancer incidence, outcomes, and responses to therapy. Analyzing the somatic mutation profiles of large-scale cancer samples between the sexes have revealed several potential drivers of cancer with ...
Chenhao Zhang +4 more
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Long Noncoding RNAs in Metabolic Syndrome Related Disorders
Mediators of Inflammation, 2016 Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (
Magdalena Losko +2 more
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The multiple ADP/ATP translocase genes are differentially expressed during human muscle development [PDF]
, 1992 The expression of the genes encoding the three isoforms of the human ADP/ATP translocase (T1, T2, and T3) has been analyzed at different stages of myogenic differentiation in an in vitro muscle cell system and compared with that in mature muscle.
Attardi, Giuseppe +3 more
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cDNA and Gene Analyses Imply a Novel Structure for a Rat Carcinoembryonic Antigen-related Protein [PDF]
, 1990 The gene encoding the human tumor marker carcinoembryonic antigen (CEA) belongs to a gene family which can be subdivided into the CEA and the pregnancy-specific glycoprotein subgroups.
Lucas, Kurt +3 more
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Down-regulatory effects of miR-211 on long non-coding RNA SOX2OT and SOX2 genes in esophageal squamous cell carcinoma [PDF]
, 2016 Objective: MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) that transcriptionally or post-Transcriptionally regulate gene expression through degradation of their mRNA targets and/or translational suppression.
Aleyasin, S.A. +4 more
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European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. [PDF]
, 2019 Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there ...
Abedi, Sina +13 more
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