Results 121 to 130 of about 224,829 (339)
Advanced Science, EarlyView.G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang +12 more
wiley +1 more source
Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights
Moleculesα-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. It has attracted considerable attention due to its versatile therapeutic potential.
Yonglian Wang +4 more
doaj +1 more source
Expression profiling of snoRNAs in normal hematopoiesis and AML [PDF]
, 2018 Key Points A subset of snoRNAs is expressed in a developmental- and lineage-specific manner during human hematopoiesis. Neither host gene expression nor alternative splicing accounted for the observed differential expression of snoRNAs in ...
Helton, Nichole +6 more
core +2 more sources
Tracking down noncoding RNAs [PDF]
Proceedings of the National Academy of Sciences, 2005 Until relatively recently, RNA has taken a predominantly backstage role compared to protein in genome studies. However, this is changing dramatically with the discovery of a plethora of RNAs that do not act as messenger (mRNA), transfer (tRNA), or ribosomal (rRNA) RNAs (1–3).
openaire +3 more sources
Advanced Science, EarlyView.Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li +10 more
wiley +1 more source
Roles of noncoding RNAs in neuropathic pain
PAIN Reports. Neuropathic pain is caused by a lesion or disease of the somatosensory (peripheral or central) nervous system. Most patients are associated with persistent or intermittent spontaneous pain.
Ziyi Guo +4 more
doaj +1 more source
Advanced Science, EarlyView.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source
Ferroptosis: Therapeutic Potential and Strategies in Non-Small Cell Lung Cancer
BiologyNon-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and a leading cause of cancer-related morbidity and mortality worldwide. Despite advancements in therapeutic strategies, the prognosis for NSCLC patients remains unfavorable ...
Ying Lei +4 more
doaj +1 more source
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway
Technology in Cancer Research & Treatment, 2020 Increasing evidence indicates the pivotal role of long noncoding RNAs in a variety of cancers, but there is limited focus on the link between long noncoding RNAs and gestational choriocarcinoma.
Qian Meng BD, Haiyan Xue MD
doaj +1 more source
Advanced Science, EarlyView.We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren +6 more
wiley +1 more source