The role of noncoding RNAs in the tumor microenvironment of hepatocellular carcinoma
Acta Biochimica et Biophysica Sinica, 2023 Hepatocellular carcinoma (HCC) is the leading fatal malignancy worldwide. The tumor microenvironment (TME) can affect the survival, proliferation, migration, and even dormancy of cancer cells.
Yang Qianqian +4 more
doaj +1 more source
The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region [PDF]
, 2019 BACKGROUND: The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types.
Andresini, Oriella +5 more
core +4 more sources
Long noncoding RNAs in prostate cancer: overview and clinical implications. [PDF]
, 2016 Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to ...
Feng, Felix Y, Malik, Bhavna
core +3 more sources
Long non-coding RNA SOX2OT: Expression signature, splicing patterns, and emerging roles in pluripotency and tumorigenesis [PDF]
, 2015 SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA which harbors one of the major regulators of pluripotency, SOX2 gene, in its intronic region.
Jazi, M.S. +3 more
core +1 more source
A new synthetic protocol for coumarin amino acid
Beilstein Journal of Organic Chemistry, 2013 The hydrochloride of the racemic amino acid (2-(7-hydroxycoumarin-4-yl)ethyl)glycine, which can serve as a fluorescent probe in proteins, and two halogen derivatives of it, were synthesized by using a new synthetic protocol in five steps.
Xinyi Xu, Xiaosong Hu, Jiangyun Wang
doaj +1 more source
A comparative analysis of lncRNAs in prostate cancer exosomes and their parental cell lines
Genomics Data, 2016 Prostate cancer is the second leading cancer in men world-wide. Due to its heterogeneous nature, a considerable amount of research effort has been dedicated in identifying effective clinical biomarkers with a focus on proteins, messenger RNA and ...
Alireza Ahadi +3 more
doaj +1 more source
Le coeur des ARN non codants - Un long chemin à découvrir [In the heart of noncoding RNA: a long way to go]. [PDF]
, 2015 The identification and characterization of long noncoding RNA in a variety of tissues represent major achievements that contribute to our understanding of the molecular mechanisms controlling gene expression.
Pedrazzini, T.
core +1 more source
p53/MicroRNA-34 axis in cancer and beyond
Heliyon, 2023 Cancer is serious endangers human life. After a long period of research and accumulation, people's understanding of cancer and the corresponding treatment methods are constantly developing. p53 is an important tumor suppressor gene.
Wei Pan +4 more
doaj +1 more source
The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]
, 2019 A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen +11 more
core +1 more source
Distinct MicroRNA Subcellular Size and Expression Patterns in Human Cancer Cells
International Journal of Cell Biology, 2012 Introduction. Small noncoding RNAs have important regulatory functions in different cell pathways. It is believed that most of them mainly play role in gene post-transcriptional regulation in the cytoplasm.
Beibei Chen +5 more
doaj +1 more source