Results 71 to 80 of about 209,431 (210)

Benchmark of computational methods for predicting microRNA-disease associations

Genome Biology, 2019
Background A series of miRNA-disease association prediction methods have been proposed to prioritize potential disease-associated miRNAs. Independent benchmarking of these methods is warranted to assess their effectiveness and robustness.
Zhou Huang, Leibo Liu, Yuanxu Gao, Jiangcheng Shi, Qinghua Cui, Jianwei Li, Yuan Zhou   +6 more
doaj   +1 more source

The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma. [PDF]

, 2018
Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules.
Burlingame, Alma, Daud, Adil, Dimon, Michelle, Esteve-Puig, Rosaura, Gajjala, Abhinay, Gho, Deborah, Ho, Wilson, Johnston, Katia, Lai, Kevin, Lin, Kevin, Moy, Adrian, Ortiz-Urda, Susana, Oses Prieto, Juan, Posch, Christian, Rappersberger, Klemens, Sanlorenzo, Martina, Vujic, Igor, Vujic, Marin, Zekhtser, Mitchell   +18 more
core   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

Noncoding RNAs in Cancer Medicine [PDF]

BioMed Research International, 2006
Several signalling proteins involved in cell growth and differentiation represent attractive candidate targets for cancer diagnosis and/or therapy since they can act as oncogenes. Because of their high specificity and low immunogeneicity, using artificial small noncoding RNA (ncRNAs) as therapeutics has recently become a highly promising and rapidly ...
Cerchia L, de Franciscis V
openaire   +3 more sources

m6Acorr: an online tool for the correction and comparison of m6A methylation profiles

BMC Bioinformatics, 2020
Background The analysis and comparison of RNA m6A methylation profiles have become increasingly important for understanding the post-transcriptional regulations of gene expression.
Jianwei Li, Yan Huang, Qinghua Cui, Yuan Zhou   +3 more
doaj   +1 more source

Noncoding RNAs in disease [PDF]

FEBS Letters, 2018
Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or ...
Lekka, Evangelia, Hall, Jonathan
openaire   +3 more sources

Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]

, 2012
Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas, Gellert, Pascal, Ponomareva, Yuliya, Uchida, Shizuka   +3 more
core   +1 more source

Decoding Noncoding RNA [PDF]

Circulation Research, 2013
The discovery by Crick, Franklin, Watson, and Wilkins of the molecule that encodes our genetic information enabled Holley, Khorana, and Nirenberg to break the 4-letter alphabet of DNA and translate it into the language of amino acids by deciphering protein-coding RNA.
Kathryn, Sandberg, Willis K, Samson, Hong, Ji   +2 more
openaire   +2 more sources

miR-32-5p suppresses the progression of hepatocellular carcinoma by regulating the GSK3β/NF-κB signaling

Acta Biochimica et Biophysica Sinica
Hepatocellular carcinoma (HCC) is a highly fatal form of malignancy that seriously threatens patient survival. The global 5-year survival rate for HCC patients ranges from 15% to 19%, and nearly 80% of patients are diagnosed at an advanced stage ...
Wang Guangzhi, Yang Qianqian, Han Yaqi, Zhang Yunlong, Pan Wei, Ma Zhongliang, Tian Hui, Qu Xudong   +7 more
doaj   +1 more source

Discovery of novel stroke-responsive lncRNAs in the mouse cortex using genome-wide RNA-seq

Neurobiology of Disease, 2017
Long noncoding RNAs (lncRNAs) play major roles in regulating gene expression in mammals, but are poorly understood in ischemic stroke. Using a mouse model of transient focal ischemia, we applied RNA-seq to evaluate for the first time the unbiased, genome-
Sunil Bhattarai, Fabrizio Pontarelli, Emily Prendergast, Ashutosh Dharap   +3 more
doaj   +1 more source