Results 61 to 70 of about 627,327 (211)

Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis

Nature Communications, 2022
Cytochalasans are a large family of fungal polyketide-nonribosomal peptide hybrid natural products that exhibit important pharmaceutical activities, but the mechanism of conversion of the monocytochalasans to the polycyclic, fused analogues is unclear ...
Jin-Mei Zhang, Xuan Liu, Qian Wei, Chuanteng Ma, Dehai Li, Yi Zou   +5 more
doaj   +1 more source

The Nonribosomal Peptide Valinomycin: From Discovery to Bioactivity and Biosynthesis

Microorganisms, 2021
Valinomycin is a nonribosomal peptide that was discovered from Streptomyces in 1955. Over the past more than six decades, it has received continuous attention due to its special chemical structure and broad biological activities.
Shuhui Huang, Yushi Liu, Wan-Qiu Liu, Peter Neubauer, Jian Li   +4 more
doaj   +1 more source

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

Nature Communications, 2019
The antimicrobial β-lactone obafluorin is produced by a Nonribosomal Peptide Synthetase (NRPS). Here the authors present the crystal structure of the obafluorin NRPS and develop a reconstitution assay that allows them to analyse product formation from ...
Dale F. Kreitler, Erin M. Gemmell, Jason E. Schaffer, Timothy A. Wencewicz, Andrew M. Gulick   +4 more
doaj   +1 more source

Diversity of Linear Non-Ribosomal Peptide in Biocontrol Fungi

Journal of Fungi, 2020
Biocontrol fungi (BFs) play a key role in regulation of pest populations. BFs produce multiple non-ribosomal peptides (NRPs) and other secondary metabolites that interact with pests, plants and microorganisms. NRPs—including linear and cyclic peptides (L-
Xiaoyan Niu, Narit Thaochan, Qiongbo Hu
doaj   +1 more source

ExMODE: A comprehensive resource for extremophile genomic and functional exploration

iMetaOmics, EarlyView.
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat‐specific non‐redundant genes, 5.25 million representative protein structures, 67,026 metagenome‐assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence‐, structure‐, and genome‐
Denghui Li, Kailong Ma, Xiaoqiang Li, Jieni Wang, Zhen Cui, Yulu Zhang, Weiwen Wang, Jiawei Tong, Yang Guo, Zongan Wang, Peiyun Zeng, Jieyu Wang, Xiaokai Xu, Nannan Zhang, Yingying Zhang, Jing Chen, Qingjiang Hu, Wenzhen Yang, Zhiyong Li, Tao Yang, Wensi Du, Zhicheng Xu, Zhen Yue, Jian Wang, Guangyi Fan, Weijia Zhang, Xun Xu, Liujie Huo, Xiaofeng Wei, Liang Meng, Shanshan Liu   +30 more
wiley   +1 more source

Dereplication and de novo sequencing of nonribosomal peptides [PDF]

Nature Methods, 2009
Nonribosomal peptides (NRPs) are of great pharmacological importance, but there is currently no technology for high-throughput NRP 'dereplication' and sequencing. We used multistage mass spectrometry followed by spectral alignment algorithms for sequencing of cyclic NRPs. We also developed an algorithm for comparative NRP dereplication that establishes
Ng, Julio, Bandeira, Nuno, Liu, Wei-Ting, Ghassemian, Majid, Simmons, Thomas L., Gerwick, William, Linington, Roger, Dorrestein, Pieter, Pevzner, Pavel   +8 more
openaire   +2 more sources

Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters in Mucoromycotina Genomes

Journal of Fungi, 2021
Early-diverging fungi harbour unprecedented diversity in terms of living forms, biological traits and genome architecture. Before the sequencing era, non-Dikarya fungi were considered unable to produce secondary metabolites (SM); however, this ...
Grzegorz Koczyk, Julia Pawłowska, Anna Muszewska   +2 more
doaj   +1 more source

Multi‐omics reveals gastrointestinal metabolic disorder‐induced diarrhea in postpartum dairy cows

iMetaOmics, EarlyView.
Nutritional diarrhea is a pervasive, costly challenge in dairy production. Using integrated metagenomic and metabolomic profiling, we identified coordinated microbial and metabolic alterations across the rumen, hindgut, and serum. In the rumen, enrichment of Prevotella sp.
Weixuan Tang, Yangyi Hao, Jiawei Zhang, Yajing Wang, Zhijun Cao, Hongjian Yang, Wei Wang, Shengli Li   +7 more
wiley   +1 more source

Comparative genomics of dark septate endophytes: shedding light on the enigmatic lifestyle and biology of DSEs

New Phytologist, EarlyView.
Ancestral lifestyle reconstruction across the phylogeny of the 107 analysed fungal genomes. Summary Dark septate endophytes (DSE) are widespread root‐colonising fungi with poorly understood lifestyle and ecological functions. We investigated their genomic traits, sexual reproduction signatures, carbohydrate‐active enzyme (CAZyme) and secondary ...
Sándor Csíkos, Zsolt Merényi, Dániel G. Knapp, Anna Lipzen, Kurt LaButti, Jasmyn Pangilinan, Robert Riley, Sajeet Haridas, Asaf Salamov, Kerrie Barry, Alan Kuo, Elodie Drula, Igor V. Grigoriev, Bernard Henrissat, Francis Martin, László G. Nagy, Gábor M. Kovács   +16 more
wiley   +1 more source

A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

, 2016
A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free
Neil Garg (2216656), Wenjun Zhang (685002), Kangjian Qiao (1458310), Yi Tang (55726), Hui Zhou (13228), Wei Xu (28953)   +5 more
core   +1 more source