Results 41 to 50 of about 627,327 (211)
, 2023 Nonribosomal peptide synthetases produce many important peptide natural products and are centred around carrier proteins (CPs) that deliver intermediates to various catalytic domains.
Tailhades, Julien +8 more
core +1 more source
Engineering DNA-Templated Nonribosomal Peptide Synthesis [PDF]
Cell Chemical Biology, 2020 Abstract Nanocontainers or macromolecular scaffolds for artificial biocatalytic cascades facilitate sequential enzyme reactions but diffusive escape of intermediates limits rate enhancement. Nonribosomal peptide synthetases (NRPS) naturally form gigantic assembly lines and prevent escape by covalently tethering intermediates.
Hsin-Mei Huang +2 more
openaire +2 more sources
Mechanistic analysis of nonribosomal peptide synthetases [PDF]
, 2021 Considering the ongoing rise of the multidrug-resistant bacterial infections, it is essential to expand the available repertoire of therapeutic agents.
Stanišić, Aleksa
core
Characterization of cereulide synthetase, a toxin-producing macromolecular machine.
PLoS ONE, 2015 Cereulide synthetase is a two-protein nonribosomal peptide synthetase system that produces a potent emetic toxin in virulent strains of Bacillus cereus.
Diego A Alonzo +2 more
doaj +1 more source
Structure, Function and Engineering of the Nonribosomal Peptide Synthetase Condensation Domain. [PDF]
Int J Mol SciThe nonribosomal peptide synthetase (NRPS) is a highly precise molecular assembly machinery for synthesizing structurally diverse peptides, which have broad medicinal applications.
Huang Z, Peng Z, Zhang M, Li X, Qiu X.
europepmc +2 more sources
Piecing together nonribosomal peptide synthesis
Current Opinion in Structural Biology, 2018 Nonribosomal peptide synthetases (NRPSs) produce peptide products with wide-ranging biological activities. NRPSs are macromolecular machines with modular assembly-line logic, a complex catalytic cycle, moving parts and multiple active sites. They are organized into repeating sets of domains, called modules.
Reimer, Janice M. +3 more
openaire +3 more sources
MicrobiologyOpen, 2016 Kalimantacin is an antimicrobial compound with strong antistaphylococcal activity that is produced by a hybrid trans‐acyltransferase polyketide synthase/nonribosomal peptide synthetase system in Pseudomonas fluorescens BCCM_ID9359.
Birgit Uytterhoeven +6 more
doaj +1 more source
Dissecting and Exploiting Nonribosomal Peptide Synthetases
Acta Biochimica et Biophysica Sinica, 2004 A large number of therapeutically useful cyclic and linear peptides of bacteria or fungal origin are synthesized via a template-directed, nucleic-acid-independent nonribosomal mechanism. This process is carried out by mega-enzymes called nonribosomal peptide synthetases (NRPSs).
Qing-Tao, Shen +3 more
openaire +2 more sources
Angewandte Chemie, Volume 138, Issue 46, 9 November 2026.The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang +6 more
wiley +2 more sources
Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
, 2016 A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide−peptide products.
Charles R. Robertson (2253277) +5 more
core +1 more source