Nonribosomal Peptide Synthesis Definitely Working Out of the Rules [PDF]
Microorganisms, 2022 Nonribosomal peptides are microbial secondary metabolites exhibiting a tremendous structural diversity and a broad range of biological activities useful in the medical and agro-ecological fields.
Matthieu Duban +2 more
doaj +2 more sources
Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis
Nature Communications, 2021 Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood.
Lin Zhong +10 more
doaj +2 more sources
Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach [PDF]
Advanced ScienceNonribosomal peptide (NRP) antibiotics exhibit potent biological activities and are broadly used in clinical therapy. Because most microorganisms are difficult to culture and many antibiotic biosynthetic genes are silent, traditional activity tracking ...
Keyi Chen +9 more
doaj +2 more sources
Life, 2020 (1) Background: Phytohabitans is a recently established genus belonging to rare actinomycetes. It has been unclear if its members have the capacity to synthesize diverse secondary metabolites.
Hisayuki Komaki, Tomohiko Tamura
doaj +2 more sources
Decoding and reprogramming fungal iterative nonribosomal peptide synthetases [PDF]
Nature Communications, 2017 Nonribosomal peptides are important bioactive molecules that are synthetized by enzymes containing several catalytic domains. Here the authors describe the catalytic mechanism of fungal nonribosomal peptide synthetases and present an approach to modify ...
Dayu Yu +3 more
doaj +2 more sources
Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases [PDF]
Marine DrugsNonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents.
Mengli Zhang +5 more
doaj +2 more sources
Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells [PDF]
Beilstein Journal of Organic ChemistryThe adenylation (A) domain is essential for non-ribosomal peptide synthetases (NRPSs), which synthesize various peptide-based natural products, including virulence factors, such as siderophores and genotoxins.
Fumihiro Ishikawa +3 more
doaj +2 more sources
BioCAT: Search for biosynthetic gene clusters producing nonribosomal peptides with known structure
Computational and Structural Biotechnology Journal, 2022 Nonribosomal peptides are a class of secondary metabolites synthesized by multimodular enzymes named nonribosomal peptide synthetases and mainly produced by bacteria and fungi.
Dmitry N. Konanov +3 more
doaj +1 more source
Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains [PDF]
, 2023 The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein ...
Jaclyn, Winter, Stephanie , Heard
core +1 more source
mSystems, 2021 Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant growth-promoting and biocontrol abilities. These secondary metabolites include nonribosomal peptides with strong antimicrobial properties, causing either cell lysis,
Heiko T. Kiesewalter +10 more
doaj +1 more source