Results 71 to 80 of about 8,679 (178)

Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

Nature Communications, 2021
Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C. Dorrestein, Helge B. Bode, Pavel A. Pevzner, Hosein Mohimani   +15 more
doaj   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Flexing and Stretching in Nonribosomal Peptide Synthetases

Chemistry & Biology, 2012
Re-engineering of nonribosomal peptide synthetase molecular assembly lines has been hampered by a lack of detailed knowledge concerning inter-domain substrate transfer. Recent structural studies of catalytically relevant domain-domain interactions provide valuable insights into this problem (Liu et al., 2011; Sundlov et al., 2012 [in this issue of ...
Pfennig, Sabrina, Stubbs, Milton T.
openaire   +2 more sources

Actinomycin Derivatives: Structural Diversification and Biological Activities

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Actinomycins are chromopeptide antibiotics exhibiting remarkable structural diversity and broad bioactivity. This review traces their development from naturally occurring D‐, X‐, A‐, G‐, Y‐, and Z‐type analogs to precursor‐directed, synthetic, and semisynthetic derivatives.
Özge Can, Erdal Bedir
wiley   +1 more source

Delftibactin-A, a Non-ribosomal Peptide With Broad Antimicrobial Activity

Frontiers in Microbiology, 2019
The rapid emergence of drug resistant bacteria is occurring worldwide, outpacing the development of new antibiotics. It is known that some of the main sources of antibiotics are the bacteria themselves, many of which are secondary metabolites of Gram ...
Noa Tejman-Yarden, Noa Tejman-Yarden, Ari Robinson, Yaakov Davidov, Alexander Shulman, Alexander Varvak, Fernando Reyes, Galia Rahav, Galia Rahav, Israel Nissan, Israel Nissan   +10 more
doaj   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala, Jade X. Tiszler, Daniel Watson, Mansi Sinha, Tony D. Davis   +4 more
wiley   +1 more source

[Biologically active nonribosomal peptides. II. Nonribosomal peptides of various biological action].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2012
The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
openaire   +2 more sources

Beneath the Bark: Molecular Determinants of Adaptation and Infection in Bacterial Pathogens of Woody Hosts

Molecular Plant Pathology, Volume 27, Issue 8, August 2026.
Bacterial pathogens colonise woody hosts by integrating metabolic adaptation, effector‐mediated immune suppression, cell wall remodelling and EPS‐ and toxin‐supported persistence. ABSTRACT Bacterial pathogens of woody plants represent a pervasive yet underexplored threat to global agriculture and forestry, causing devastating diseases in fruit trees ...
Antonio Arroyo‐Mateo, Jesús Murillo, Luis Rodríguez‐Moreno, Cayo Ramos   +3 more
wiley   +1 more source

Structural basis of nonribosomal peptide macrocyclization in fungi [PDF]

Nature Chemical Biology, 2016
Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex ...
Jinru, Zhang, Nicholas, Liu, Ralph A, Cacho, Zhou, Gong, Zhu, Liu, Wenming, Qin, Chun, Tang, Yi, Tang, Jiahai, Zhou   +8 more
openaire   +2 more sources