A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum. [PDF]
PLoS ONE, 2014 The filamentous fungus Penicillium chrysogenum harbors an astonishing variety of nonribosomal peptide synthetase genes, which encode proteins known to produce complex bioactive metabolites from simple building blocks. Here we report a novel non-canonical
Hazrat Ali +10 more
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Structural, biochemical and bioinformatic analyses of nonribosomal peptide synthetase adenylation domains [PDF]
, 2023 The adenylation reaction has been a subject of scientific intrigue since it was first recognized as essential to many biological processes, including the homeostasis and pathogenicity of some bacteria and the activation of amino acids for protein ...
Jaclyn, Winter, Stephanie , Heard
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Antibacterial Property Of A Coral-Associated Bacterium Pseudoalteromonas Luteoviolacea Against Shrimp Pathogenic Vibrio Harveyi(In Vitro Study) [PDF]
, 2004 A coral-associated bacterium was successfully screened for secondary metabolites production based on PCR amplification of the non-ribosomal peptide synthetase gene and was identified as closely related to Pseudoalteromonas luteoviolacea based on its 16S ...
Grossart, Hans-Peter +5 more
core +2 more sources
Hayati Journal of Biosciences, 2005 A coral-associated bacterium was successfully screened for secondary metabolites production based on PCR amplification of the nonribosomal peptide synthetase gene and was identified as closely related to Pseudoalteromonas luteoviolacea based on its 16S ...
OCKY KARNA RADJASA +5 more
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Investigation of Indigoidine Synthetase Reveals a Conserved Active-Site Base Residue of Nonribosomal Peptide Synthetase Oxidases [PDF]
, 2020 Nonribosomal peptide synthetase (NRPS) oxidase (Ox) domains oxidize protein-bound intermediates to install crucial structural motifs in bioactive natural products. The mechanism of this domain remains elusive.
Gan, Fei +7 more
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Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849T
Fermentation, 2023 Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has
Hisayuki Komaki, Tomohiko Tamura
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mBio, 2020 Nonribosomal peptide synthetases (NRPSs) and polyketide synthetases (PKSs) play a pivotal role in the production of bioactive natural products, such as antibiotics and cytotoxins. Despite biomedical and pharmaceutical importance, the molecular mechanisms
A. Gacek-Matthews +5 more
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Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target [PDF]
, 2010 Nonribosomal peptide synthetases (NRPSs) are large multimodular and multidomain enzymes that are involved in synthesising an array of molecules that are important in human and animal health.
Lee, TV +11 more
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Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism. [PDF]
PLoS ONE, 2015 In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining ...
Jiri Janata +11 more
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Identification of a conserved N‐terminal domain in the first module of ACV synthetases
MicrobiologyOpen, 2021 The l‐δ‐(α‐aminoadipoyl)‐l‐cysteinyl‐d‐valine synthetase (ACVS) is a trimodular nonribosomal peptide synthetase (NRPS) that provides the peptide precursor for the synthesis of β‐lactams.
Riccardo Iacovelli +3 more
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