Results 1 to 10 of about 7,845 (216)

Noradrenergic dysfunction in Alzheimer's disease [PDF]

Frontiers in Neuroscience, 2015
The brain noradrenergic system supplies the neurotransmitter norepinephrine throughout the brain via widespread efferent projections, and plays a pivotal role in modulating cognitive activities in the cortex.
Mary Gannon, Kai Jiao, Erik D Roberson
exaly   +6 more sources

The Noradrenergic System in Parkinson’s Disease [PDF]

Frontiers in Pharmacology, 2020
Nowadays it is well accepted that in Parkinson’s disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological ...
Elena Paredes-rodriguez, Teresa Morera-herreras, Philippe De Deurwaerdère   +2 more
exaly   +7 more sources

Noradrenergic modulation of arousal [PDF]

Brain Research Reviews, 2008
Through a highly divergent efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of locus coeruleus neurons has long-suggested a role of this system in the induction of an alert waking state.
Craig W Berridge
exaly   +4 more sources

Noradrenergic Source of Dopamine Assessed by Microdialysis in the Medial Prefrontal Cortex

Frontiers in Pharmacology, 2020
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from ...
Paola Devoto, Claudia Sagheddu, Marco Pistis   +2 more
exaly   +3 more sources

Simulation of cholinergic and noradrenergic modulation of behavior in uncertain environments

Frontiers in Computational Neuroscience, 2012
Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes.
Andrea A Chiba, Jeffrey L Krichmar, Giorgio Gnavi   +2 more
exaly   +3 more sources

The turnover rate of noradrenergic vesicles [PDF]

Biochemical Journal, 1971
W.P. De Potter, I.W. Chubb
openalex   +4 more sources

Perioperative Sedation and Sympatholysis Due to Tizanidine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Tizanidine is a short acting central muscle relaxant. It has agonist activity at noradrenergic alpha 2 receptors and inhibits the excitatory (presynaptic) motor neurons at both the spinal and supraspinal levels.
Situ, Girish Kumar Singh, Hari Haran Gnaneswaran   +2 more
doaj   +1 more source

A mechanism linking perinatal 2,3,7,8 tetrachlorodibenzo-p-dioxin exposure to lower urinary tract dysfunction in adulthood

Disease Models & Mechanisms, 2021
Benign prostatic hyperplasia/lower urinary tract dysfunction (LUTD) affects nearly all men. Symptoms typically present in the fifth or sixth decade and progressively worsen over the remainder of life. Here, we identify a surprising origin of this disease
Anne E. Turco, Steven R. Oakes, Kimberly P. Keil Stietz, Cheryl L. Dunham, Diya B. Joseph, Thrishna S. Chathurvedula, Nicholas M. Girardi, Andrew J. Schneider, Joseph Gawdzik, Celeste M. Sheftel, Peiqing Wang, Zunyi Wang, Dale E. Bjorling, William A. Ricke, Weiping Tang, Laura L. Hernandez, Janet R. Keast, Adrian D. Bonev, Matthew D. Grimes, Douglas W. Strand, Nathan R. Tykocki, Robyn L. Tanguay, Richard E. Peterson, Chad M. Vezina   +23 more
doaj   +1 more source

Associations between the use of β-adrenoceptor acting drugs and the risk of dementia in older population

Frontiers in Neurology, 2022
ObjectiveAge-related decline within the noradrenergic system is associated with reduced cognition. The β-adrenoceptors are widely expressed in the brain as well as in the peripheral.
Shishuang Cui, Shishuang Cui, Fang Fang, Fang Fang, Peijing Cui, Peijing Cui, Qianwen Jiang, Qianwen Jiang, Shaoqing Xu, Shaoqing Xu, Zhihong Xu, Zhihong Xu, Jia'An Hu, Jia'An Hu, Feika Li, Feika Li   +15 more
doaj   +1 more source

Depression and/or PTSD Comorbidity Affects Response to Antidepressants in Those With Alcohol Use Disorder

Frontiers in Psychiatry, 2022
Objective: Depression and post-traumatic stress disorder (PTSD) highly co-occur with alcohol use disorder (AUD). The comparative effects of noradrenergic vs.
Peter J. Na, Peter J. Na, Elizabeth Ralevski, Elizabeth Ralevski, Oluwole Jegede, Aaron Wolfgang, Ismene L. Petrakis, Ismene L. Petrakis   +7 more
doaj   +1 more source