Results 11 to 20 of about 41,607 (263)

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

open access: yesFrontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt   +5 more
doaj   +1 more source

Satiation and stress-induced hypophagia: examining the role of hindbrain neurons expressing prolactin-releasing peptide (PrRP) or glucagon-like peptide 1 (GLP-1)

open access: yesFrontiers in Neuroscience, 2013
Neural circuits distributed within the brainstem, hypothalamus, and limbic forebrain interact to control food intake and energy balance under normal day-to-day conditions, and in response to stressful conditions under which homeostasis is threatened ...
James W. Maniscalco   +2 more
doaj   +1 more source

Analgesic Effects of Bee Venom Derived Phospholipase A2 in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain

open access: yesToxins, 2015
A single infusion of oxaliplatin, which is widely used to treat metastatic colorectal cancer, induces specific sensory neurotoxicity signs that are triggered or aggravated when exposed to cold or mechanical stimuli.
Dongxing Li   +5 more
doaj   +1 more source

Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders

open access: yesFrontiers in Molecular Neuroscience, 2023
SLITRK1 is a neuronal transmembrane protein with neurite development-and synaptic formation-controlling abilities. Several rare variants of SLITRK1 have been identified and implicated in the pathogenesis of Tourette’s syndrome, trichotillomania, and ...
Minoru Hatayama, Jun Aruga
doaj   +1 more source

Neuromodulation and a Reconceptualization of Autism Spectrum Disorders: Using the Locus Coeruleus Functioning as an Exemplar

open access: yesFrontiers in Neurology, 2018
The Autism Spectrum Disorders (ASD) are a heterogeneous group of developmental disorders. Although, ASD can be reliably diagnosed, the etiology, pathophysiology, and treatment targets remain poorly characterized. While there are many atypical findings in
Eric B. London
doaj   +1 more source

Anoxia at Birth Induces Behaviorally-Relevant Changes in alpha2-Noradrenergic Receptor Binding in the Adult Rat

open access: yesMcGill Journal of Medicine, 2020
Evidence suggests that Caesarean section birth in the rat, with or without an additional period of anoxia, results in long-term changes in brain catecholamine levels as well as reactivity to stress.
Wayne G. Brake, Shakti Sharma
doaj   +1 more source

Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis

open access: yesFrontiers in Immunology, 2017
The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans.
Donald B. Hoover   +7 more
doaj   +1 more source

Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition

open access: yesScientific Reports, 2023
Chronic pain and attention-deficit hyperactivity disorder (ADHD) frequently coexist. However, the common pathology is still unclear. Attenuated noradrenergic endogenous analgesia can produce acute pain chronification, and dysfunction of noradrenergic ...
Takashi Suto   +7 more
doaj   +1 more source

PTSD: from neurobiology to pharmacological treatments

open access: yesEuropean Journal of Psychotraumatology, 2016
Posttraumatic stress disorder (PTSD) is a chronic debilitating psychiatric disorder characterized by symptoms of re-experience, avoidance, and hyperarousal that can arise immediately or many years after exposure to a traumatic event and injury.
Benjamin Kelmendi   +5 more
doaj   +1 more source

Sex-dependent noradrenergic modulation of premotor cortex during decision-making

open access: yeseLife, 2023
Rodent premotor cortex (M2) integrates information from sensory and cognitive networks for action planning during goal-directed decision-making. M2 function is regulated by cortical inputs and ascending neuromodulators, including norepinephrine (NE ...
Ellen M Rodberg   +3 more
doaj   +1 more source

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