Results 211 to 220 of about 100,759 (296)

Nose to brain delivery of nanostructured lipid carriers loaded with rivastigmine and nilotinib for treating Alzheimer's disease: preparation, cell line study, and in vivo evaluation. [PDF]

Discov Nano
Khan SA, Qamar Z, Kamboj S, Moonis M, Rai G, Dang S, Singh PP, Alam O, Parvez S, Baboota S, Ali J.   +10 more
europepmc   +1 more source

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype‐Guided AI for ANKRD11 Missense Variants

Clinical Genetics, EarlyView.
PhenoScore, an AI framework integrating facial recognition and clinical phenotype data, accurately identifies pathogenic ANKRD11 missense variants associated with KBG syndrome (AUC 0.95). Validated against functional data, PhenoScore outperforms REVEL and complements AlphaMissense, providing objective phenotypic evidence to reduce variants of uncertain
Evi Andriessen, Elke de Boer, Gholson J. Lyon, Bert B. A. de Vries, Charlotte W. Ockeloen, Alexander J. M. Dingemans   +5 more
wiley   +1 more source

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged <i>β</i>-amyloid nanoscavenger for Alzheimer's disease therapy. [PDF]

Acta Pharm Sin B
Xu Y, Ye X, Du Y, Yang W, Tong F, Li W, Huang Q, Chen Y, Li H, Gao H, Zhang W.   +10 more
europepmc   +1 more source

Longitudinal Analysis of Sleep‐Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia

Clinical Otolaryngology, EarlyView.
ABSTRACT Objectives Sleep‐disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.
Shifa Hamdule, Melanie Koelbel, Johanna C. Gavlak, Sati Sahota, Fenella J. Kirkham, Anna M. Hood   +5 more
wiley   +1 more source

In Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer's Disease Therapy. [PDF]

Int J Mol Sci
Lee D, Shen AM, Shah M, Garbuzenko OB, Minko T.   +4 more
europepmc   +1 more source

Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies. [PDF]

Pharmaceuticals (Basel)
El Sisi AM, Eissa EM, Hassan AHE, Bekhet MA, El-Ela FIA, Roh EJ, Kharshoum RM, Ali AA.   +7 more
europepmc   +1 more source

Promising brain biodistribution of insulin via intranasal dry powder for nose-to-brain delivery. [PDF]

Heliyon
Muntu CM, Avanti C, Hayun, Surini S.
europepmc   +1 more source

Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via the Minimally Invasive Nasal Depot (MIND) Technique. [PDF]

ACS Appl Mater Interfaces
Di Francesco V, Chua AJ, Bleier BS, Amiji MM.   +3 more
europepmc   +1 more source

Assessing the Credibility of ChatGPT on Temporomandibular Disorders

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Large Language Models such as ChatGPT are increasingly used in dental education; however, their credibility in clinical contexts remains uncertain. This study is aimed to analyse the credibility and efficacy of responses given by ChatGPT about temporomandibular disorders among dentists and dental students.
Hilal Yilanci, Amr Anjary, Mohammed Adleh   +2 more
wiley   +1 more source