Results 81 to 90 of about 100,759 (296)
Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [PDF]
, 2009 Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein.
Ko, Jan +2 more
core +2 more sources
The Oneiric Reality of Electronic Scents [PDF]
, 2014 This paper investigates the ‘oneiric’ dimension of scent, by suggesting a new design process that can be worn as a fashion accessory or integrated in textile technologies, to subtly alter reality and go beyond our senses.
Lahiri, Kim +2 more
core
Non-invasive aerosol delivery and transport of gold nanoparticles to the brain [PDF]
, 2017 Targeted delivery of nanoscale carriers containing packaged payloads to the central nervous system has potential use in many diagnostic and therapeutic applications. Moreover, understanding of the bio-interactions of the engineered nanoparticles used for
Biswas, Pratim +4 more
core +2 more sources
Advanced Science, EarlyView.We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong +8 more
wiley +1 more source
Pharmaceutics, 2018 The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in central nervous system (CNS) drug delivery, since they block most molecules from entering the brain.
Stella Gänger, Katharina Schindowski
doaj +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Bioactive MaterialsWith the aging of the population, the incidence of Alzheimer's disease (AD) has increased dramatically, causing severe medical, care, and economic burdens on society and families.
Xiao Yue +13 more
doaj +1 more source
RVG29-modified microRNA-loaded nanoparticles improve ischemic brain injury by nasal delivery
Drug Delivery, 2020 Effective nose-to-brain delivery needs to be developed to treat neurodegenerative diseases. Regulating miR-124 can effectively improve the symptoms of ischemic brain injury and provide a certain protective effect from brain damage after cerebral ischemia.
Rubin Hao +4 more
doaj +1 more source
Transcriptional regulation of copper metabolism genes in the liver of fetal and neonatal control and iron-deficient rats [PDF]
, 2014 Acknowledgments The authors’ work is supported by Scottish Government (Rural and Environmental Scientific and Analytical Services). We are grateful to Ms Val Stevens for analytical and technical assistance and to the Biological Resource Facility staff ...
Hayes, Helen +3 more
core +2 more sources
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott +15 more
wiley +1 more source