Results 21 to 30 of about 4,816,902 (277)

Screening Unknown Novel Psychoactive Substances Using GC-MS Based Machine Learning [PDF]

open access: yes, 2022
In recent years, there is a large increase in structural diversity of novel psychoactive substances (NPS), exacerbating drug abuse issues as these variants evade classical detection methods such as spectral library matching.
Swee Liang, Wong   +3 more
core   +1 more source

A Focus on Abuse/Misuse and Withdrawal Issues with Selective Serotonin Reuptake Inhibitors (SSRIs): Analysis of Both the European EMA and the US FAERS Pharmacovigilance Databases

open access: yesPharmaceuticals, 2022
Despite increasing reports, antidepressant (AD) misuse and dependence remain underestimated issues, possibly due to limited epidemiological and pharmacovigilance evidence.
Stefania Chiappini   +5 more
doaj   +1 more source

Novel psychoactive substances: a novel clinical challenge [PDF]

open access: yesBMJ Case Reports, 2013
The recreational use of novel psychoactive substances in the UK has increased markedly within the last decade. The variety of new substances synthesised and sold as ‘legal’, often under the pretence of being ‘plant food’ or ‘bath salts’ is similarly increasing. This presents challenges to clinicians: they may be unaware of these substances or unable to
Christopher Daniel, Smith   +2 more
openaire   +2 more sources

Stimulant and hallucinogenic novel psychoactive substances; an update [PDF]

open access: yesExpert Review of Clinical Pharmacology, 2023
The renewed interest in considering a range of stimulants, psychedelics and dissociatives as therapeutics emphasizes the need to draft an updated overview of these drugs' clinical and pharmacological issues.The focus here was on: stimulants (e.g. amphetamines, methamphetamine, and pseudoephedrine; phenethylamines; synthetic cathinones; benzofurans ...
F, Schifano   +3 more
openaire   +3 more sources

Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signalling [PDF]

open access: yes, 2015
Novel psychoactive substances are newly used designer drugs ("internet drugs", "research chemicals", "legal highs") potentially posing similar health risks to classic illicit substances. Chemically, many novel psychoactive substances can be classified as
Liechti, Matthias E., Matthias Liechti
core   +1 more source

What about “Pharming”? Issues Regarding the Misuse of Prescription and Over-the-Counter Drugs

open access: yesBrain Sciences, 2020
Recently, a range of prescription and over-the-counter (OTC) drugs have emerged as being used recreationally, either on their own or in combination with other substances, both licit and illicit, including new psychoactive substances (NPS).
Stefania Chiappini, Fabrizio Schifano
doaj   +1 more source

Novel Psychoactive Substances (NPS) profile in South Gloucestershire [PDF]

open access: yes, 2014
Novel Psychoactive Substances (NPS) are chemical substances that have been synthesised to cause similar reactions to those produced by taking conventional drugs. The report estimates the prevalence of NPS use across South Gloucestershire.
Ismail, Nasrul
core   +1 more source

Pharmacovigilance Signals of the Opioid Epidemic over 10 Years: Data Mining Methods in the Analysis of Pharmacovigilance Datasets Collecting Adverse Drug Reactions (ADRs) Reported to EudraVigilance (EV) and the FDA Adverse Event Reporting System (FAERS)

open access: yesPharmaceuticals, 2022
In the past twenty years, the consumption of opioid medications has reached significant proportions, leading to a rise in drug misuse and abuse and increased opioid dependence and related fatalities.
Stefania Chiappini   +6 more
doaj   +1 more source

Genotoxicity Evaluation of The Novel Psychoactive Substance MTTA

open access: yesInternational Journal of Molecular Sciences, 2023
MTTA, also known as mephtetramine, is a stimulant novel psychoactive substance characterized by a simil-cathinonic structure. To date, little has been studied on its pharmaco-toxicological profile, and its genotoxic potential has never been assessed. In order to fill this gap, the aim of the present work was to evaluate its genotoxicity on TK6 cells in
Monia Lenzi   +4 more
openaire   +3 more sources

Could Hallucinogens Induce Permanent Pupillary Changes in (Ab)users? A Case Report from New Zealand

open access: yesCase Reports in Neurological Medicine, 2017
An eighteen-year-old female patient of the Caucasian ethnicity from Australasia presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when she is outdoors due to oversensitivity to sunlight.
Ahmed Al-Imam
doaj   +1 more source

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