Results 111 to 120 of about 57,135 (271)

Clinical validation of a DNA methylation biomarker associated with overall survival of relapsed ovarian cancer patients

open access: yesInternational Journal of Cancer, Volume 158, Issue 7, Page 1821-1835, 1 April 2026.
What's new? Most patients with ovarian cancer (OC) relapse after first‐line chemotherapy, and prognosis with second‐line treatment depends largely on the platinum‐free interval. However, reliable biomarkers to predict response to second‐line therapy remain lacking.
Muhammad Habiburrahman   +7 more
wiley   +1 more source

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

open access: yesNeurobiology of Disease, 2018
Neuropeptide Y (NPY) is an important 36 amino acid peptide that is abundantly expressed in the mammalian CNS and is known to be an endogenous modulator of seizure activity, including in rat models of Genetic Generalised Epilepsy (GGE) with absence ...
Kim L. Powell   +7 more
doaj   +1 more source

Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse [PDF]

open access: yes, 2013
Background Inhibitory interneurons in the superficial dorsal horn play important roles in modulating sensory transmission, and these roles are thought to be performed by distinct functional populations. We have identified 4 non-overlapping classes among
Garzillo, F.   +4 more
core   +2 more sources

GeoFWI: A Large Velocity Model Data Set for Benchmarking Full Waveform Inversion Using Deep Learning

open access: yesJournal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 2, April 2026.
Abstract Full waveform inversion (FWI) plays an increasingly important role in the field of seismic imaging due to its strong ability to estimate subsurface properties. Specifically, data‐driven FWI (DDFWI) establishes a straightforward mapping relationship between seismic data and the corresponding velocity model, yielding promising results.
Chao Li   +5 more
wiley   +1 more source

Signal Amplification in the HPT Axis—Evidence for Its Existence, Location, Significance, and Molecular Mechanisms

open access: yesActa Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Thyroid hormones (THs) are under negative feedback regulation via the hypothalamic–pituitary‐thyroid (HPT) axis. How this axis operates to keep the circulating THs within a narrow physiological range is not well understood quantitatively. Led by the design principle of robust homeostatic feedback control, here we review and synthesize the ...
Li Jing, Sarahna A. Moyd, Qiang Zhang
wiley   +1 more source

Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model

open access: yesIndian Journal of Endocrinology and Metabolism, 2012
Neuropeptide Y (NPY) is a neuropeptide widely expressed in the brain and a peptide transmitter of sympathetic nervous system (SNS) co-released with noradrenaline (NA) in prolonged stress.
Suvi T Ruohonen   +2 more
doaj   +1 more source

Checkerboard style Schur multiple zeta values and odd single zeta values

open access: yes, 2017
We give explicit formulas for the recently introduced Schur multiple zeta values, which generalize multiple zeta(-star) values and which assign to a Young tableaux a real number.
Bachmann, Henrik, Yamasaki, Yoshinori
core   +1 more source

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]

open access: yes, 2019
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Abba, Martín Carlos   +11 more
core   +2 more sources

Diabetic kidney disease, biomarkers, and finerenone

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.
Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
wiley   +1 more source

Mouse circadian plasma leptin and active ghrelin rhythms under ad libitum and scheduled feeding [PDF]

open access: yes, 2007
Thesis (M.S.) University of Alaska Fairbanks, 2007Light is the strongest timing cue for the circadian system, but non-photic cues can also entrain the master circadian clock, i.e., suprachiasmatic nuclei (SCN).
Wan, Haiting
core  

Home - About - Disclaimer - Privacy