Results 141 to 150 of about 69,085 (277)
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei +10 more
wiley +1 more source
A UK study: vocational experiences of young adults with juvenile idiopathic arthritis
Laura E. Lunt +7 more
doaj +1 more source
Distortions to Global Agricultural Markets: What Next? [PDF]
A decline in governmental distortions to agricultural and other trade since the 1980s has contributed to economic growth and poverty alleviation globally.
Anderson, Kym
core +1 more source
Spatial heterogeneity of antibody–drug conjugate targets in pancreatic ductal adenocarcinoma
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with limited therapeutic options, few patients showing targetable molecular changes. New therapeutic strategies are necessary. Antibody–drug conjugates (ADCs) have emerged as alternative therapeutic strategies across various cancer types. Herein, we analyze the expression and spatial
Deema Sabtan +10 more
wiley +1 more source
How do governments respond to food price spikes ? lessons from the past [PDF]
Food prices in international markets spiked upward in 2008, doubling or more in a matter of months. Evidence is still being compiled on policy responses over the following two years, but lessons can be learned from the price spike in 1973, the magnitude ...
Anderson, Kym, Nelgen, Signe
core
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang +14 more
wiley +1 more source
Extramedullary Disease—Achilles Heel in Myeloma?
ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar +7 more
wiley +1 more source
De novo design of Ras isoform selective binders. [PDF]
Zhang JZ +8 more
europepmc +1 more source

