Results 141 to 150 of about 69,085 (277)

Frequent NPM1 mutation, monoblastic/monocytic origin and prognostic significance of organ and system involvement in myeloid sarcoma: a multicenter study

open access: yesThe Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei   +10 more
wiley   +1 more source

A UK study: vocational experiences of young adults with juvenile idiopathic arthritis

open access: yesPediatric Rheumatology Online Journal, 2019
Laura E. Lunt   +7 more
doaj   +1 more source

Distortions to Global Agricultural Markets: What Next? [PDF]

open access: yes
A decline in governmental distortions to agricultural and other trade since the 1980s has contributed to economic growth and poverty alleviation globally.
Anderson, Kym
core   +1 more source

Spatial heterogeneity of antibody–drug conjugate targets in pancreatic ductal adenocarcinoma

open access: yesThe Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, with limited therapeutic options, few patients showing targetable molecular changes. New therapeutic strategies are necessary. Antibody–drug conjugates (ADCs) have emerged as alternative therapeutic strategies across various cancer types. Herein, we analyze the expression and spatial
Deema Sabtan   +10 more
wiley   +1 more source

Influence of information provided prior to switching from Humira to biosimilar adalimumab on UK patients’ satisfaction: a cross-sectional survey by patient organisations

open access: yesBMJ Open, 2022
Peter C Taylor   +7 more
doaj   +1 more source

How do governments respond to food price spikes ? lessons from the past [PDF]

open access: yes
Food prices in international markets spiked upward in 2008, doubling or more in a matter of months. Evidence is still being compiled on policy responses over the following two years, but lessons can be learned from the price spike in 1973, the magnitude ...
Anderson, Kym, Nelgen, Signe
core  

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang   +14 more
wiley   +1 more source

Extramedullary Disease—Achilles Heel in Myeloma?

open access: yesAmerican Journal of Hematology, Volume 101, Issue 3, Page 521-536, March 2026.
ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar   +7 more
wiley   +1 more source

De novo design of Ras isoform selective binders. [PDF]

open access: yesCell Chem Biol
Zhang JZ   +8 more
europepmc   +1 more source

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