Results 11 to 20 of about 69,085 (277)
Journal of Advanced Biotechnology and Experimental Therapeutics, 2022 The MAPK-ERK, as well as PI3K-AKT signaling transduction pathway, represents a pivotal function in tumorigenesis. Genetic alterations of potential tumor-driven genes, for instance, KRAS, BRAF, NRAS, and PIK3CA can result in uncontrolled cell ...
Linh Dieu Vuong +2 more
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Somatic mutations in colorectal cancer: regional experience
Consilium Medicum, 2022 Introduction. Colorectal cancer is one of the most common malignant neoplasms in economically developed countries, ranking 3rd and 2nd in the structure of morbidity and mortality, respectively. Current knowledge about the molecular features of colorectal
Nikolai A. Ognerubov, Elena N. Ezhova
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Chronic Myelomonocytic Leukemia: Hematopathology Perspective [PDF]
Journal of Immunotherapy and Precision Oncology, 2021 Our understanding of chronic myelomonocytic leukemia (CMML) has evolved tremendously over the past decade. Large-scale sequencing studies have led to increased insight into the genomic landscape of CMML and clinical implications of these changes. This in
Siba El Hussein +4 more
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Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022 Colorectal cancer is one of the most frequently diagnosed malignant tumors in men and women, which is a highly heterogeneous group of neoplasms consisting of subclasses with different molecular and clinical characteristics, and, as a consequence ...
A. N. Toropovskiy +5 more
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Prognostic value of somatic mutation testing and different methods of treatment of low-risk differentiated thyroid cancer [PDF]
Эндокринная хирургия, 2019 Background: Using molecular testing for prediction the course of the disease could possibly help doctors in making therapeutic decisions about the management of patients, because it remains controversial issues in low-risk differentiated thyroid cancer ...
Vera A. Kachko +2 more
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Molecular genetic testing in colon cancer: clinical aspects
Alʹmanah Kliničeskoj Mediciny, 2022 Molecular genetic diagnostics is an essential element to plan for management of colorectal cancer (CRC) patients. The choice of systemic treatment for CRC is impossible without molecular testing of the tumor.
Aleksandr S. Martianov +3 more
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Somatic mutation testing: the role in differential diagnosis of thyroid neoplasms [PDF]
Эндокринная хирургия, 2019 Background: In the preoperative diagnosis of thyroid tumors the cytological examination of the material of fine needle aspiration biopsy is the gold standard and serves as the basis for planning of treatment strategy.
Vera A. Kachko +5 more
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Сибирский онкологический журнал, 2020 Purpose: to evaluate the effect of somatic mutations of the KRAS, NRAS, BRAF genes and the status of microsatellite instability on the overall and disease-free survival of patients undergoing cytoreductive surgery with hyperthermic intraperitoneal ...
V. P. Shubin +6 more
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NRAS, NRAS, Which Mutation Is Fairest of Them All? [PDF]
Journal of Investigative Dermatology, 2016 In 28% of melanomas, NRAS is mutated in one of two hotspots: G12 or Q61. Phosphoproteomic analysis of primary human melanocytes transduced with G12 and Q61 showed different phosphorylation events in the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways.
Grill, Christine, Larue, Lionel
openaire +2 more sources
CRAF R391W is a melanoma driver oncogene. [PDF]
, 2016 Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad +11 more
core +7 more sources