Results 221 to 230 of about 45,512 (293)

Signaling Mutations Negate the Favorable Impact of NPM1 Mutations in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Treated With VEN/HMA. [PDF]

Am J Hematol
Hoff FW, Zeidner JF, Torlapati G, Nicolet D, Mrózek K, Huang Y, Li A, Welkie RL, Swords RT, Traer E, Stein EM, Lin TL, Baer MR, Duong VH, Blum WG, Arellano ML, Stock W, Odenike O, Olin RL, Smith CC, Schiller GJ, Curran EK, Chan O, McMahon C, Hochman M, Sahasrabudhe K, Foucar C, Gonzalez-Lugo J, Knick Ragon B, Handa SV, Heerema NA, Chen T, Martycz M, Stefanos M, Marcus SG, Rosenberg L, Druker BJ, Levine RL, Burd A, Yocum AO, Borate UM, Mims AS, Eisfeld AK, Byrd JC, Madanat YF.   +44 more
europepmc   +1 more source

KRAS Mutations in Cancers: From Undruggable Dilemma to Precision Medicine

MedComm, Volume 7, Issue 10, October 2026.
KRAS‐mutant cancers are therapeutically shaped by both allele identity and tumor context. Direct KRAS inhibition has achieved the greatest clinical success in KRAS G12C‐mutant NSCLC, whereas colorectal cancer often requires EGFR cotargeting and pancreatic cancer remains constrained by stromal and metabolic barriers. Shared resistance mechanisms include
Jiaying Cai, Yimin Wu, Xing Jia, Li Yang, Wenjun Yang, Weishan Lu, Zhiye Huang, Yang Pan, Zixuan Fei, Junnan Ru, Jiazheng Zhao, Jue Shen, Taobo Luo, Da Chen, Haihong Yu, Haihan Deng, Jian Zeng, Wenmei Jiang, Leilei Wu   +18 more
wiley   +1 more source

Moving beyond a legacy paradigm: A vision for equitable access to quality medicines in Africa. [PDF]

Int J Gynaecol Obstet
Doi N, Orji BC, Ruffo M, Mukumbayi P, Kibonge S, Muthamia MM, Tappis H, Biayi F, Kassim TY, Ndwiga A.   +9 more
europepmc   +1 more source

The Diagnostic Performance of Afirma Genomic Sequencing Classifier in Black and Hispanic Patients With Indeterminate Thyroid Nodules

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 4, Page 849-858, October 2026.
Abstract Objective About 20% of thyroid nodules detected on ultrasound are cytologically indeterminate (Bethesda categories III and IV), but the rate of malignancy of these nodules is less than 36%. The ability of Afirma Genomic Sequencing Classifier (GSC) to further risk‐stratify indeterminate thyroid nodules among Black and Hispanic patients is ...
Peter J. Attia, Sree Chinta, Joseph Celidonio, John Sebastian De Armas, Evelyne Kalyoussef, Dylan F. Roden   +5 more
wiley   +1 more source

Lung-Predominant Hyperinflammatory Syndrome in Therapy-Related Myelodysplastic Syndrome Responsive to Interleukin-1 Blockade. [PDF]

Hematol Rep
Smith Q, Arar-Cauley A.
europepmc   +1 more source

Capacity and limitations of US wild meat donation programmes

People and Nature, Volume 8, Issue 10, Page 3215-3220, October 2026.
Abstract Historically, sharing of wild harvests to facilitate food security followed concepts of kin selection and reciprocal altruism. However, cultural shifts have reduced access to foods for some populations in modern times. Cultural altruism through sustainably harvested wild meat donation programmes (WDPs) can reduce food and nutritional ...
David S. Mason, Mark E. Bell, Kenneth F. Kellner, Chad M. Stewart, Jerrold L. Belant   +4 more
wiley   +1 more source

Artificial Intelligence-Based Prediction of Molecular Alterations in Colorectal Cancer Using Routine H&E Whole-Slide Images. [PDF]

Int J Mol Sci
Popa MF, Șiancu P, Mohor CI, Oprinca-Muja LA, Oprinca GC, Mohor CI, Tănăsescu C, Tănăsescu D, Cristian A, Vereș VV, Bereanu A.   +10 more
europepmc   +1 more source

Protein Profile of Multiple Myeloma‐Derived Extracellular Vesicles for the Discovery of Novel Myeloma‐Related Biomarkers

Cancer Science, Volume 117, Issue 10, Page 2877-2890, October 2026.
Comparison of extracellular vesicles with parental cells through proteomic profiling, followed by an integrated bioinformatic pipeline including disease association and transcriptomic analyses, identifies candidate biomarkers for multiple myeloma. Among these, MIF emerges as a clinically relevant marker, supported by validation in patient samples and ...
Natalia Platonova, Gilda Aiello, Domenica Ronchetti, Valentina Citro, Rosanna Asselta, Lavinia Casati, Domenica Giannandrea, Elisa Taiana, Antonino Neri, Gloria Sini, Elisabetta Calzavara, Mauro Turrini, Alfonsina D'Amato, Raffaella Chiaramonte   +13 more
wiley   +1 more source

Accelerating Global Access for Indication Extension Through Regulatory Reliance Pilot: The First Indication Extension Pilot in Oncology. [PDF]

Ther Innov Regul Sci
Litsiou A, Snow MJ, Morgan E, Shah P, Cabarrot A, Davies R.   +5 more
europepmc   +1 more source

Clinical and Genetic Profile of One Molecularly Confirmed and One Clinically Suspected Case of LZTR1 ‐Related Noonan Syndrome

Clinical Genetics, Volume 110, Issue 4, Page 502-507, October 2026.
This study illustrates the phenotypic variability of LZTR1‐related Noonan syndrome type 10 in two pediatric patients, including presentations without congenital heart defects. The findings emphasize the importance of whole‐exome sequencing and longitudinal re‐evaluation of variants of uncertain significance in achieving accurate diagnosis.
Karolina Skrzyńska, Barbara Kalina‐Faska, Ewa Błaszczyk, Aneta Gawlik‐Starzyk   +3 more
wiley   +1 more source