Results 231 to 240 of about 45,512 (293)

Systemic inflammation and prognosis in patients with RAS/BRAF wild‐type metastatic colorectal cancer receiving anti‐EGFR therapy: A real‐world cohort study

Colorectal Disease, Volume 28, Issue 10, October 2026.
Abstract Aim Colorectal cancer outcomes are heterogeneous, so greater prognostic discrimination is needed. In this retrospective real‐world analysis, we assessed the prognostic effect of markers of systemic inflammation in a cohort of patients with RAS/BRAF wild‐type metastatic colorectal cancer (mCRC) who received anti‐EGFR therapy during routine care.
Jordan W. Appleyard, Faye Elliott, Nancy L. Sapanara, Liping Zhang, Uday Kurkure, Jenny F. Seligmann, Nicholas P. West, Kandavel Shanmugam, Philip Quirke, Christopher J. M. Williams, on behalf of the N6 Collaboration   +10 more
wiley   +1 more source

Patterns of <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> mutations in colorectal cancer in Chile: a 3-year real-world evidence [2019-2021]-a brief report. [PDF]

J Gastrointest Oncol
Chávez FS, De la Torre PR, Flores W, Cueto N, Villanueva MG, Veas-Torres J, Miranda DI, Barriga FS, Avendaño ME, Abello CSM, Sabioncello H AC, Sáez MA, Brito MN, Flores TM, Barrios H, Godoy JA, Garrido M.   +16 more
europepmc   +1 more source

Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics

Journal of Cutaneous Pathology, Volume 53, Issue 10, Page 917-920, October 2026.
ABSTRACT Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families.
Jessica L. Muldoon, Laura M. Warmke, Ahmed K. Alomari, Rachel P. Kowal   +3 more
wiley   +1 more source

Aligning Licensure and Recommended Use to Expedite Vaccine Access in Response to the Ongoing Bundibugyo Ebolavirus Epidemic in Central Africa. [PDF]

Viruses
O'Hara GL, Halabi S.
europepmc   +1 more source

Introduced dung beetles suppress methane emissions from cattle dung and alter the temporal dynamics of greenhouse gas flux Los escarabajos peloteros introducidos suprimen las emisiones de metano del estiércol de ganado y alteran la dinámica temporal del flujo de gases de efecto invernadero Besouros coprófagos introduzidos suprimem as emissões de metano do esterco bovino e alteram a dinâmica temporal do fluxo de gases de efeito estufa

Ecological Entomology, Volume 51, Issue 5, Page 1025-1035, October 2026.
Dung beetles suppressed cumulative methane flux from cattle dung by 85% and reduced total greenhouse gas emissions by 18%. Beetle activity accelerated initial CO2 release but did not alter total cumulative flux. N2O and NH3 fluxes were transient and not consistently driven by beetle presence.
Jean Holley, Martin Brummell, Nigel R. Andrew   +2 more
wiley   +1 more source

Temperature and lipid composition differentially regulate KRAS assemblies on membranes.

Chem Commun (Camb)
Kang J, Scott E, Yun SD, James VK, Chang JY, Bahramimoghaddam H, Downing J, Evans K, Russell DH, Laganowsky A.   +9 more
europepmc   +1 more source

Activity of Direct KRAS(G12C) Inhibitors in Preclinical Models of Pediatric Cancer. [PDF]

Mol Cancer Ther
Price HE, Stauffer S, Lee H, Isanogle KA, Wu Y, Powell K, Baker A, Stauffer L, Perciaccante AJ, Jewell CP, Hernandez ER, Aljabri AK, Odeniyide P, Pratilas CA, Burgan W, Edmondson EF, Difilippantonio S, Kortum RL, Shern JF, Jenkins LM, Rossman KL, Yohe ME.   +21 more
europepmc   +1 more source

Spatial Proteomics as a Potential Decision‐Support Layer for Early Melanoma: A Narrative Review

International Journal of Dermatology, Volume 65, Issue S1, Page S35-S45, October 2026.
This schematic illustrates a proposed, future multimodal diagnostic framework in which spatial proteomics, AI‐based digital pathology, and clinical data would be integrated to support the evaluation of borderline melanocytic lesions. The figure depicts a conceptual research direction rather than a workflow currently available or validated for clinical ...
Leticia Szadai, Jeovanis Gil, György Marko‐Varga   +2 more
wiley   +1 more source

A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia. [PDF]

iScience
Jones L, Rukhlenko O, Dias T, Imoto H, Carmody C, Wynne K, Kholodenko BN, Bond J.   +7 more
europepmc   +1 more source

Mutation Patterns Define Clinical Heterogeneity in Acute Myeloid Leukemia. [PDF]

J Cancer
Xu Z, Zheng Y, Zheng Y, Yao Y, Geng H, Li X, Wang SY, Pan L.   +7 more
europepmc   +1 more source