Results 211 to 220 of about 69,773 (297)

Advancing Pharmacometrics in Africa: Insights and Perspectives From the 2025 Pharmacometrics Africa Conference

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1216-1222, May 2026.
Pharmacometrics (PMX) in Africa has transitioned from foundational capacity‐building to job creation, scientific leadership, regulatory influence, and health innovation. To accelerate this progress, the 2025 Pharmacometrics Africa Conference (PMXAC‐2025) convened key stakeholders to consolidate the continental PMX community, review progress in local ...
Babatunde Ayodeji Adeagbo, Innocent Gerald Asiimwe, Linda Chaba, Aida N. Kawuma, Francis Williams Ojara, Ochuko Maureen Orherhe, Simon Peter Asiimwe, Veshni Pillay‐Fuentes Lorente, Sharon Sawe, Cassius M. Phogole, Catriona Waitt, Samer Mouksassi, Goonaseelan (Colin) Pillai   +12 more
wiley   +1 more source

Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma. [PDF]

Cancer Res
Cui G, Zhou Y, Liao W, Cossu E, Evert M, Zhang S, Wang J, Deng S, Yonemura A, David L, Xu M, Doumergue JM, Lu X, Yang L, Li J, Liang B, Wang H, Xu H, Zhong S, Deng Y, Calvisi DF, Zhao J, Chen X, Wang X.   +23 more
europepmc   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signaling in Melanoma Cells. [PDF]

Int J Mol Sci
Yakovian O, Sajman J, Sherman E.
europepmc   +1 more source

Activating NRAS Mutation [PDF]

, 2020
openaire   +1 more source

Analysis of Somatic Mutations and Immunotherapy Biomarkers in Chinese Patients With Non‐Small Cell Lung Cancer During 2019–2024: A Retrospective Study

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Understanding genetic alterations in lung cancer remains challenging due to tumor heterogeneity and malignancy. This study aimed to investigate somatic variations and immune‐related biomarkers in Chinese patients with NSCLC.
Xiumei Liu, Weigong Chen, Chengqi Xin, Zexu Wang, Kaiyu Yi, Liang Wang, Jing Liu   +6 more
wiley   +1 more source

NRAS NP_002515.1:p.G12S [PDF]

, 2020
openaire   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Efficacy of azacitidine and trametinib against leptomeningeal melanosis associated with congenital melanocytic nevus syndrome. [PDF]

Mol Cell Pediatr
Raljević L, Komlosi K, Feige U, Eckenweiler M, Lassmann S, Jrad HBH, Werner M, Fischer J, Has C, Feuchtinger T, Uhl M, Niemeyer CM, Hettmer S.   +12 more
europepmc   +1 more source

NRAS NP_002515.1:p.Q61K [PDF]

, 2020
openaire   +1 more source