Results 61 to 70 of about 69,085 (277)
Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia
American Journal of Hematology, EarlyView.ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball +11 more
wiley +1 more source
Geophysical Monograph Series, Page 97-104., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Daniele Cherniak +2 more
wiley +2 more sources
, 2014 We present a method to characterize the spatial coherence of soft X-ray radiation from a single diffraction pattern. The technique is based on scattering from non-redundant arrays (NRA) of slits and records the degree of spatial coherence at several ...
Bach, J. +18 more
core +1 more source
Chasing the observational signatures of seed black holes at z > 7: Candidate statistics [PDF]
, 2018 Supermassive black holes (SMBHs) of 109–1010M were already in place ∼13 Gyr ago, at z > 6. Super-Eddington growth of low-mass BH seeds (∼100M) or less extreme accretion on to∼105M seeds have been recently considered as the main viable routes to these ...
Graziani, Luca +5 more
core +1 more source
American Journal of Industrial Medicine, EarlyView.ABSTRACT Background Existing research on the economic outcomes of 9/11 remains limited and has primarily focused on early retirement. Little is known about the prevalence of work disability and loss of a loved one and whether they are associated with survey attrition.
Jennifer Brite +2 more
wiley +1 more source
Communications MedicineBackground Melanoma is an aggressive form of skin cancer, and patients with NRAS-mutant melanoma face limited treatment options due to the lack of direct NRAS inhibitors.
Valentin Feichtenschlager +16 more
doaj +1 more source
Scientific Reports, 2021 Circular RNAs have emerged as functional regulatory molecules whose aberrant expression has been linked to diverse pathophysiological processes. Here, we report that circPVT1 interferes with let-7 binding to NRAS, confirming this axis as one route by ...
Joshua Miguel C. Danac +1 more
doaj +1 more source
Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio +16 more
wiley +1 more source
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma
Nature CommunicationsActivating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K,
Yalei Wen +18 more
doaj +1 more source
NRAS destines tumor cells to the lungs
EMBO Molecular Medicine, 2017 The lungs are frequently affected by cancer metastasis. Although NRAS mutations have been associated with metastatic potential, their exact role in lung homing is incompletely understood.
Anastasios D Giannou +19 more
doaj +1 more source