Results 1 to 10 of about 200,244 (343)

The Effect of high-intensity interval training with coenzyme Q10 supplementation on the Nrf2 and NQO1 in soleus muscle of older rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2023
Background and Purpose: Increased oxidative stress is the main characteristic of all types of age-related injuries. Based on the role of physical activity in adaptive responses to oxidative stress and importance of nutritional supplements, the aim of ...
Zahra Noruzi, Javad Nemati, Mohsen Salesi, Rasoul Rezai, Mohammad Hemmatinafar   +4 more
doaj   +1 more source

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]

, 2017
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L., Deeni, Yusuf Y., Hamza Kankia, Ibrahim, Khalil, Hilal S., Langdon, Simon P., Moult, Peter R.   +5 more
core   +14 more sources

Antioxidant Activity of Unripe Sapodilla Fruit Extract (Manilkara zapota L.) through Nrf2 and SOD Expression in Type 1 Diabetic Mice

Journal of Tropical Life Science, 2023
This research aims to analyze the effect of unripe sapodilla fruit extract on endogenous antioxidant expression in T1DM BALB/c mice and its free radical scavenging activity.
Muhaimin Rifa'i, Fikriya Novita Sari, Rizky Senna Samoedra, Setyaki Kevin Pratama, Sri Rahayu, Aris Soewondo, Muhammad Halim Natsir   +6 more
doaj   +1 more source

The importance of polymorphisms of regulatory and catalytic antioxidant proteins in chronic kidney disease [PDF]

Medicinski Podmladak, 2021
Both excessive production of reactive oxygen species (ROS) and impaired antioxidant function are found in patients with chronic kidney disease (CKD).
Jerotić Đurđa, Matić Marija, McClements Lana   +2 more
doaj   +1 more source

Understanding the molecular basis of vitiligo - a systematic review

Journal of Education, Health and Sport, 2023
Introduction: Vitiligo is a systemic, chronic, hypopigmented dermatosis of unclear background. The disease is characterized by the selective loss or dysfunction of melanocytes.
Magdalena Osuch, Magdalena Gaik, Rafał Bogacz, Ewa Uram, Justyna Woźniak, Karol Womperski, Inga Magda   +6 more
doaj   +1 more source

Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Ginger has protective effects on the kidney, however the molecular mechanism of this effect has not yet been fully elucidated. Therefore, this work studied molecular mechanisms of ginger effects on ethanol-induced kidney injury.
Rozita Fathi, Abolfazl Akbari, Khadijeh Nasiri, Marjan Chardahcherik   +3 more
doaj   +1 more source

Pancreatic β-cell protective effect of novel GABA derivatives in rats with type 2 diabetes

Research Results in Pharmacology, 2023
Introduction: Gamma-aminobutyric acid (GABA) and GABAergic compounds emerged as potential therapeutic agents for diabetes mellitus and its complications.
Ivan N. Tyurenkov, Dmitry A. Bakulin, Yulia I. Velikorodnaya, Alexander V. Borisov, Elizaveta E. Abrosimova, Alexey V. Smirnov, Grigoriy L. Snigur, Svyatoslav S. Surin, Daria A. Kavalerova, Olga S. Vasilyeva   +9 more
doaj   +1 more source

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]

, 2020
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A., DeNicola, Gina M., Elkins, Cody M., Falzone, Aimee, Haura, Eric B., Prieto-Farigua, Nicolas, Torrente, Laura   +6 more
core   +1 more source

Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention [PDF]

, 2014
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1-5 µM) to promote cell proliferation to 120-143% of the controls in a number of human cell lines, whilst at high levels (10-40 µM) it inhibited such cell proliferation.
A Arlt, A Giudice, A Herman-Antosiewicz, A Lau, A Lister, A Melchini, A Speciale, AA Alfadda, AJ Vargas, AT Dinkova-Kostova, AV Gasper, C Cornelius, C Fimognari, C Fimognari, Changhao Sun, CR Zhao, D Li, D Rand, D Ren, Daotai Nie, DD Zhang, DS Michaud, E Warwick, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, ER Hahm, F Ekiz, F Galgano, F Zanichelli, GM DeNicola, GR Fenwick, GS Omenn, HK Na, I Misiewicz, I Oehme, IS Santos, J Jakubikova, J Watson, JD Clarke, JD Hayes, JD Watson, JM Cramer, K Pietsch, K Suppipat, KA Moy, KL Cheung, L Gamet-Payrastre, L Kuang, L Ye, LN Barrera, LS Cooley, M McMahon, MB Sporn, MP Mattson, MP Mattson, P Sestili, P Shelton, PE Miller, R Brigelius-Flohe, RF Clayton, RK Thimmulappa, S Homma, SA McNaughton, SJ Jackson, SL Navarro, T Hara, T Nishikawa, T Xu, TG Son, TW Kensler, TW Kensler, V Calabrese, V Rungapamestry, W Hendrickx, Wei Wang, X Ma, X Yu, XJ Wang, Y Ji, Y Li, Y Mitsuishi, Y Shan, Y Zhang, Y Zhang, Y Zhang, Y Zhang, YJ Surh, Yongping Bao, YS Keum, Zhigang Zhou   +91 more
core   +14 more sources

Protective effects of N-acetyl-l-cysteine against penconazole-triggered hepatorenal toxicity in adult rats

Journal of Veterinary Research, 2023
Penconazole (PEN) is a widely applied triazole fungicide. This study sought to define the efficacy of N-acetyl-l-cysteine (NAC) in mitigating PEN-triggered hepatorenal toxicity in rats.
Morgan Ashraf M., Ogaly Hanan A., Kamel Shaimaa, Rashad Maha M., Hassanen Eman I., Ibrahim Marwa A., Galal Mona K., Yassin Aya M., Dulmani Sharah A. Al, Al-Zahrani Fatimah A.M., Hussien Ahmed M.   +10 more
doaj   +1 more source