Results 91 to 100 of about 225,391 (343)

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

Frontiers in Oncology, 2023
Cancer is a borderless global health challenge that continues to threaten human health. Studies have found that oxidative stress (OS) is often associated with the etiology of many diseases, especially the aging process and cancer.
Li Lin, Qing Wu, Feifei Lu, Jiaming Lei, Yanhong Zhou, Yifei Liu, Ni Zhu, You Yu, Zhifeng Ning, Tonghui She, Meichun Hu   +10 more
semanticscholar   +1 more source

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. [PDF]

, 2019
BackgroundThe transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance ...
Cheng, Jing-Yan, Cheng, Kai-Chun, Hsu, Huan-Ming, Liang, Yuh-Jin, Lin, Ruey-Jen, Wang, Sheng-Hung, Wu, Jen-Chine, Yu, Alice L, Yu, John, Yu, Jyh-Cherng   +9 more
core   +1 more source

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Nrf2 signaling and cell survival [PDF]

Toxicology and Applied Pharmacology, 2010
Nrf2:INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to link Nrf2 to the ubiquitin ligase Cul3-Rbx1 complex that ubiquitinate and degrade Nrf2. Under basal conditions, cytosolic INrf2/Cul3-Rbx1 is constantly degrading Nrf2.
Suryakant K, Niture, James W, Kaspar, Jun, Shen, Anil K, Jaiswal   +3 more
openaire   +2 more sources

Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections

Frontiers in Bioscience-Landmark
Mycoplasmas are the smallest cell-wall-less self-replicating prokaryotes. Mycoplasma species can be found within and outside cells as “silent parasites” that live intracellularly and as membrane surface parasites.
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo   +4 more
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway [Retraction]

Journal of Inflammation Research, 2022
Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S. J Inflamm Res. 2021;14:7393–7409. The Editor and Publisher of Journal of Inflammation Research wish to retract the published article.
Alvi AM, Shah FA, Muhammad AJ, Feng J, Li S   +4 more
doaj  

Is a Meal without Wine Good for Health?

Diseases, 2018
Hippocrates, the father of medicine, had said: “Wine is a thing wonderfully appropriate to man if, in health as in disease, it is administered with appropriate and just measure according to the individual constitution.„ Wine has always ...
Jean-Pierre Rifler
doaj   +1 more source

The Nrf2-HO-1 system and inflammaging

Frontiers in Immunology
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1 ...
Sinead A. O'Rourke, Lianne C. Shanley, A. Dunne   +2 more
semanticscholar   +1 more source